TABLE 3
From the following article:
Patterns of somatic mutation in human cancer genomes
Christopher Greenman, Philip Stephens, Raffaella Smith, Gillian L. Dalgliesh, Christopher Hunter, Graham Bignell, Helen Davies, Jon Teague, Adam Butler, Claire Stevens, Sarah Edkins, Sarah O'Meara, Imre Vastrik, Esther E. Schmidt, Tim Avis, Syd Barthorpe, Gurpreet Bhamra, Gemma Buck, Bhudipa Choudhury, Jody Clements, Jennifer Cole, Ed Dicks, Simon Forbes, Kris Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jon Hinton, Andy Jenkinson, David Jones, Andy Menzies, Tatiana Mironenko, Janet Perry, Keiran Raine, Dave Richardson, Rebecca Shepherd, Alexandra Small, Calli Tofts, Jennifer Varian, Tony Webb, Sofie West, Sara Widaa, Andy Yates, Daniel P. Cahill, David N. Louis, Peter Goldstraw, Andrew G. Nicholson, Francis Brasseur, Leendert Looijenga, Barbara L. Weber, Yoke-Eng Chiew, Anna deFazio, Mel F. Greaves, Anthony R. Green, Peter Campbell, Ewan Birney, Douglas F. Easton, Georgia Chenevix-Trench, Min-Han Tan, Sok Kean Khoo, Bin Tean Teh, Siu Tsan Yuen, Suet Yi Leung, Richard Wooster, P. Andrew Futreal and Michael R. Stratton
Nature 446, 153-158(8 March 2007)
doi:10.1038/nature05610
Table 3. Protein kinase genes ranked by probability of carrying at least one driver mutation, conditional on the gene-specific selection pressures..
| Gene | Ranking (95% confidence interval) | Selection pressure | Number ofnon-synonymous mutations |
|---|---|---|---|
The top 20 protein kinase genes are shown. See Supplementary Information for the ranking and selection pressures for all 518 genes. | |||
| TTN | 1 (1–3) | 2.036 | 63 |
| BRAF | 2 (1–67) | 8.362 | 8 |
| ATM | 3 (2–150) | 2.920 | 10 |
| TAF1L | 4 (2–145) | 3.588 | 8 |
| ERN1 | 5 (2–151) | 4.538 | 6 |
| MAP2K4 | 6 (2–156) | 8.665 | 4 |
| CHUK | 7 (2–205) | 5.392 | 5 |
| FGFR2 | 8 (2–210) | 5.096 | 5 |
| NTRK3 | 9 (2–518) | 4.808 | 5 |
| MGC42105 | 10 (2–170) | 7.097 | 4 |
| TGFBR2 | 11 (2–187) | 5.877 | 4 |
| EPHA6 | 12 (3–518) | 3.949 | 5 |
| FLJ23074 | 13 (3–193) | 5.403 | 4 |
| ITK | 14 (3–203) | 4.887 | 4 |
| DCAMKL3 | 15 (3–204) | 4.714 | 4 |
| STK11 | 16 (3–518) | 7.160 | 3 |
| PAK7 | 17 (3–518) | 4.215 | 4 |
| STK6 | 18 (3–518) | 6.018 | 3 |
| BRD2 | 19 (4–518) | 3.773 | 4 |
| RPS6KA2 | 20 (4–518) | 3.722 | 4 |
