A technique for precisely timed intervention in mouse development.
doi:10.1038/7131xia
Table of contents
Volume 446 Number 7131 ppE1-102
(this content only available online) indicates content that is available online only
Making the paper: Karen Liu pxi
Abstractions pxi
doi:10.1038/7131xib
Key postdocs pxi
doi:10.1038/7131xic
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Editorials
Trial and failure p1
Only the most promising AIDS gels should reach large-scale trials.
doi:10.1038/446001a
Solid foundations p1
In praise of those physicists who are unobtrusively revolutionizing everyday life.
doi:10.1038/446001b
Not saving the whale p2
Japan's professed interest in whale research rings rather hollow.
doi:10.1038/446002a
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News
Death toll in Iraq: survey team takes on its critics p6
Raw data should settle arguments over study methods.
Jim Giles
doi:10.1038/446006a
Q&A: Ronald Plasterk p7
Meet the human metabolome p8
Can body fluids succeed where genomics and proteomics have failed?
Helen Pearson
doi:10.1038/446008a
Letting the light in on Antarctic ecosystems p9
Ice-shelf collapse offers glimpse of life beneath the South Pole.
Lucy Odling-Smee
doi:10.1038/446009a
The lab that asked the wrong questions p10
Closure of parapsychology lab throws spotlight on scientific taboos.
Lucy Odling-Smee
doi:10.1038/446010a
Data sharing: the next generation p10
Social software offers fresh perspectives on results.
Declan Butler
doi:10.1038/446010b
Sidelines p11
doi:10.1038/446011a
Scientists rethink approach to HIV gels p12
Tough decisions follow failure of clinical trial.
Erika Check
doi:10.1038/446012a
Trio of studies makes headway in HIV battle p12
Techniques to curb transmission offer hope in fight against AIDS.
Erika Check
doi:10.1038/446012b
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Business
A merger too far? p15
Bristol-Myers Squibb has been stoking its research productivity. Meredith Wadman investigates whether an acquisition would be the right prescription for the company.
doi:10.1038/446015a
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News Features
Laser physics: Extreme light p16
Physicists are planning lasers powerful enough to rip apart the fabric of space and time. Ed Gerstner is impressed.
Ed Gerstner
doi:10.1038/446016a
Science of hair: The roots of accomplishment p20
From a New Jersey beauty parlour to cutting-edge genetics by way of her own alopecia, Angela Christiano's life has all been tied up with hair. Helen Pearson meets a woman whose head is full of the stuff that covers it.
Helen Pearson
doi:10.1038/446020a
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Business Feature
Radar satellites: Mountains to molehills p22
As radar satellites reach ever higher resolutions, they are exciting both scientists and the military. Can they make money too? Quirin Schiermeier reports.
Quirin Schiermeier
doi:10.1038/446022a
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Correspondence
Potential downsides of perfect pain relief p24
Need to distinguish science (good or bad) from ethics p24
Never mind the footprint, get the mass right p24
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Books and Arts
Into the darkness p25
Cosmologists face some tough challenges as they explore the composition of the Universe.
doi:10.1038/446025a
The roots of complex problems p26
doi:10.1038/446026a
New in Paperback p26
doi:10.1038/446026b
Fascinating rhythm p27
doi:10.1038/446027a
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Essay
ConnectionsProtecting biostructure p29
Biodiversity researchers have focused on diversity at the cost of ignoring the networks of interactions between organisms that characterize ecosystems.
Kevin McCann
doi:10.1038/446029a
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News and Views
物理：重力がテストに合格
Physics: Gravity passes a little test p31
Newton's gravity, that old classical warhorse, is well established on scales as large as the Solar System. The latest experimental confirmation of its validity is tiny in scale, but big in implications.
Clive Speake
doi:10.1038/446031a
日本語要約 | Full Text | PDF (416K)
生理学：漏れるチャネルのうれしくない遺産
Physiology: Legacy of leaky channels p32
Mutations that affect the opening and closing of ion channels in cell membranes are associated with disease. Defects in other properties of these channels can also cause ion leakage, with equally devastating consequences.
Richard Horn
doi:10.1038/446032a
日本語要約 | Full Text | PDF (423K)
50 & 100 Years Ago p34
doi:10.1038/446034a
顕微鏡法：原子の指紋
Microscopy: Atomic fingerprinting p34
Atomic force microscopy is a well-established technique to image all kinds of surfaces at the atomic scale. But the force patterns that emerge can also pin down the chemical identity of individual atoms.
Alexander Shluger & Tom Trevethan
doi:10.1038/446034b
日本語要約 | Full Text | PDF (221K)
ウイルス学：天然結晶の構造を探る
Virology: Holed up in a natural crystal p35
Insect viruses that cause polyhedrosis produce infectious microcrystals within a cell. These inclusions were used in a study that pushed the state of the crystallographic art to explain their exceptional stability.
Felix A. Rey
doi:10.1038/446035a
日本語要約 | Full Text | PDF (573K)
材料科学：薄っぺらなものの研究
Materials science: Flaky research p36
フォトニクス：格子上に局在する光
Photonics: Light localized on the lattice p37
Photonic lattices are materials specially designed to cage light. By shaking the mesh of the cage, we can see how light, initially passing freely, finds its room for manoeuvre progressively restricted.
Z. Valy Vardeny & Mikhail Raikh
doi:10.1038/446037a
日本語要約 | Full Text | PDF (417K)
細胞生物学：異数性と癌
Cell biology: Aneuploidy and cancer p38
Aneuploidy is the condition in which a cell has extra or missing chromosomes, and is often associated with tumours. But whether it is a cause or a consequence of cancer remains a vexed question.
David Pellman
doi:10.1038/446038a
日本語要約 | Full Text | PDF (532K)
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Brief Communications Arising
Climate modelling: Uncertainty in climate-sensitivity estimates pE1
Climate modelling: Uncertainty in climate-sensitivity estimates (Reply) pE2
Gabriele C. Hegerl, Thomas J. Crowley, William T. Hyde & David J. Frame
doi:10.1038/nature05708
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Articles
生理：CD38はオキシトシン分泌を制御して社会行動に重要な役割を果たす
CD38 is critical for social behaviour by regulating oxytocin secretion p41
Duo Jin, Hong-Xiang Liu, Hirokazu Hirai, Takashi Torashima, Taku Nagai, Olga Lopatina, Natalia A. Shnayder, Kiyofumi Yamada, Mami Noda, Toshihiro Seike, Kyota Fujita, Shin Takasawa, Shigeru Yokoyama, Keita Koizumi, Yoshitake Shiraishi, Shigenori Tanaka, Minako Hashii, Toru Yoshihara, Kazuhiro Higashida, Mohammad Saharul Islam, Nobuaki Yamada, Kenshi Hayashi, Naoya Noguchi, Ichiro Kato, Hiroshi Okamoto, Akihiro Matsushima, Alla Salmina, Toshio Munesue, Nobuaki Shimizu, Sumiko Mochida, Masahide Asano & Haruhiro Higashida
doi:10.1038/nature05526
細胞：酵母におけるMAPKを介した双峰性遺伝子発現と適応性勾配感知
MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast p46
Saurabh Paliwal, Pablo A. Iglesias, Kyle Campbell, Zoe Hilioti, Alex Groisman & Andre Levchenko
doi:10.1038/nature05561
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Chemical rescue of cleft palate and midline defects in conditional GSK-3
Letters
物理：乱れた2次元フォトニック格子における輸送とアンダーソン局在
Transport and Anderson localization in disordered two-dimensional photonic lattices p52
Tal Schwartz, Guy Bartal, Shmuel Fishman & Mordechai Segev
doi:10.1038/nature05623
物理：グラフェン中のバイポーラー超伝導電流
Bipolar supercurrent in graphene p56
Hubert B. Heersche, Pablo Jarillo-Herrero, Jeroen B. Oostinga, Lieven M. K. Vandersypen & Alberto F. Morpurgo
doi:10.1038/nature05555
材料：宙づりにしたグラフェンシートの構造
The structure of suspended graphene sheets p60
Jannik C. Meyer, A. K. Geim, M. I. Katsnelson, K. S. Novoselov, T. J. Booth & S. Roth
doi:10.1038/nature05545
日本語要約 | Full Text | PDF (1,027K) | Supplementary information
顕微鏡法：原子間力顕微鏡法による個々の表面原子の化学識別
Chemical identification of individual surface atoms by atomic force microscopy p64
Yoshiaki Sugimoto, Pablo Pou, Masayuki Abe, Pavel Jelinek, Rubén Pérez, Seizo Morita & Óscar Custance
doi:10.1038/nature05530
日本語要約 | Full Text | PDF (1,043K) | Supplementary information
地球：MgSiO3鉱物中の転移のモデル化が示唆するマントル深部塑性流動
Implications for plastic flow in the deep mantle from modelling dislocations in MgSiO3 minerals p68
Philippe Carrez, Denise Ferré & Patrick Cordier
doi:10.1038/nature05593
日本語要約 | Full Text | PDF (3,437K) | Supplementary information
神経：脊髄中の動員の地理的対応マップ
A topographic map of recruitment in spinal cord p71
David L. McLean, Jingyi Fan, Shin-ichi Higashijima, Melina E. Hale & Joseph R. Fetcho
doi:10.1038/nature05588
生理：遺伝性のイオンチャネル病におけるゲート孔電流
Gating pore current in an inherited ion channelopathy p76
Stanislav Sokolov, Todd Scheuer & William A. Catterall
doi:10.1038/nature05598
発生：条件的GSK-3βマウスにおける口蓋裂と正中線異常の薬剤による救済
Chemical rescue of cleft palate and midline defects in conditional GSK-3
mice p79
Karen J. Liu, Joseph R. Arron, Kryn Stankunas, Gerald R. Crabtree & Michael T. Longaker
doi:10.1038/nature05557
免疫：胚中心のin vivo画像から明らかになった動的な開いた構造
In vivo imaging of germinal centres reveals a dynamic open structure p83
Tanja A. Schwickert, Randall L. Lindquist, Guy Shakhar, Geulah Livshits, Dimitris Skokos, Marie H. Kosco-Vilbois, Michael L. Dustin & Michel C. Nussenzweig
doi:10.1038/nature05573
日本語要約 | Full Text | PDF (1,630K) | Supplementary information
細胞：赤内型熱帯熱マラリア原虫におけるミトコンドリア電子伝達の特殊な役割
Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum p88
Heather J. Painter, Joanne M. Morrisey, Michael W. Mather & Akhil B. Vaidya
doi:10.1038/nature05572
免疫：トランスフェリン受容体1は新世界出血熱アレナウイルスの細胞受容体である
Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses p92
Sheli R. Radoshitzky, Jonathan Abraham, Christina F. Spiropoulou, Jens H. Kuhn, Dan Nguyen, Wenhui Li, Jane Nagel, Paul J. Schmidt, Jack H. Nunberg, Nancy C. Andrews, Michael Farzan & Hyeryun Choe
doi:10.1038/nature05539
生化学：サイポウイルス多角体の分子構築
The molecular organization of cypovirus polyhedra p97
Fasséli Coulibaly, Elaine Chiu, Keiko Ikeda, Sascha Gutmann, Peter W. Haebel, Clemens Schulze-Briese, Hajime Mori & Peter Metcalf
doi:10.1038/nature05628
日本語要約 | Full Text | PDF (1,456K) | Supplementary information
Top of page
Erratum
Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages p102
Kohki Kawane, Mayumi Ohtani, Keiko Miwa, Takuji Kizawa, Yoshiyuki Kanbara, Yoshichika Yoshioka, Hideki Yoshikawa & Shigekazu Nagata
doi:10.1038/nature05581
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Addendum
Artificial 'spin ice' in a geometrically frustrated lattice of nanoscale ferromagnetic islands p102
R. F. Wang, C. Nisoli, R. S. Freitas, J. Li, W. McConville, B. J. Cooley, M. S. Lund, N. Samarth, C. Leighton, V. H. Crespi & P. Schiffer
doi:10.1038/nature05607
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Corrigenda
A Mesozoic gliding mammal from northeastern China p102
Jin Meng, Yaoming Hu, Yuanqing Wang, Xiaolin Wang & Chuankui Li
doi:10.1038/nature05639
Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis p102
Sonya S. Glasson, Roger Askew, Barbara Sheppard, Brenda Carito, Tracey Blanchet, Hak-Ling Ma, Carl R. Flannery, Diane Peluso, Kim Kanki, Zhiyong Yang, Manas K. Majumdar & Elisabeth A. Morris
doi:10.1038/nature05640
Genetically modified Plasmodium parasites as a protective experimental malaria vaccine p102
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Special Report
Career Views
Recruiters
Highlights
Naturejobs
ProspectProspects p103
Origami expert illustrates the power of creative transformation.
Paul Smaglik
doi:10.1038/nj7131-103a
Special Report
Getting in the frame p104
The conditions for framework funding are complex and the competition is tough, says Nora Eichinger. But many find the prize is worth the effort.
Nora Eichinger
doi:10.1038/nj7131-104a
Career Views
Tim de Zeeuw, director-general, European Southern Observatory, Garching, Germany p106
Astronomy goes from theories of galaxy shapes to realities of observatory management.
Virginia Gewin
doi:10.1038/nj7131-106a
Hub of alternative energy p106
BP's Energy Biosciences Institute brings jobs and research opportunities to Berkeley.
Virginia Gewin
doi:10.1038/nj7131-106b
On resilience p106
Postodc takes time to tie her shoelaces.
Maria Ocampo-Hafalla
doi:10.1038/nj7131-106c
Recruiters
The inside track from academia and industry: Temporary display p108
If you look on short-term employment as a way of window shopping, you could get a bargain.
Martin Lang
doi:10.1038/nj7131-108a
Highlights
Highlight: European Opportunities
doi:10.1038/nj0147
Opportunities: The National Institutes of Health
doi:10.1038/nj0148
