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Nature 446, 38-39 (1 March 2007) | doi:10.1038/446038a; Published online 28 February 2007
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Head-Preclinical
- Syngene International
- Bangalore, Karnataka 560099 India
Postdoctoral Opportunity in Cancer Research - Molecular Biologist / Molecular Pathologist, at the IARC / WHO in Lyons, France : Lyons, France
- International Agency for Research on Cancer (IARC / WHO)
- Lyon 69008 France
Cell biology: Aneuploidy and cancer
David Pellman1
Abstract
Aneuploidy is the condition in which a cell has extra or missing chromosomes, and is often associated with tumours. But whether it is a cause or a consequence of cancer remains a vexed question.
Aneuploid cancers are like Tolstoy's unhappy families: each aneuploid cancer has its own particular abnormal chromosome content, and thus its own abnormal characteristics. This variability has long frustrated biologists trying to establish whether aneuploidy is a cause or a consequence of malignant transformation.
- David Pellman is at the Dana-Farber Cancer Institute, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Email: david_pellman@dfci.harvard.edu
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RESEARCH
Cell biology Nondisjunction, aneuploidy and tetraploidyNature Brief Communication (17 Aug 2006)
Apoptosis regulation in tetraploid cancer cellsThe EMBO Journal Article (07 Jun 2006)
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