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Nature 446, 35-37 (1 March 2007) | doi:10.1038/446035a; Published online 28 February 2007
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Virology: Holed up in a natural crystal
Felix A. Rey1
Abstract
Insect viruses that cause polyhedrosis produce infectious microcrystals within a cell. These inclusions were used in a study that pushed the state of the crystallographic art to explain their exceptional stability.
Much of structural biology relies on obtaining highly ordered crystals of proteins and other macromolecules, and it often takes considerable time and effort to produce crystals of adequate quality. In some cases, however, proteins crystallize spontaneously in vivo.
- Felix A. Rey is in the Unité de Virologie Structurale (CNRS URA 3015), Département de Virologie, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France.
Email: rey@pasteur.fr
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