Mutations that affect the opening and closing of ion channels in cell membranes are associated with disease. Defects in other properties of these channels can also cause ion leakage, with equally devastating consequences.
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Horn, R. Legacy of leaky channels. Nature 446, 32–34 (2007). https://doi.org/10.1038/446032a
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DOI: https://doi.org/10.1038/446032a
