Table of contents
Volume 446 Number 7131 pp1-108
(this content only available online) indicates content that is available online only
Editorials
Trial and failure p1
Only the most promising AIDS gels should reach large-scale trials.
doi:10.1038/446001a
Solid foundations p1
In praise of those physicists who are unobtrusively revolutionizing everyday life.
doi:10.1038/446001b
Not saving the whale p2
Japan's professed interest in whale research rings rather hollow.
doi:10.1038/446002a
News
Death toll in Iraq: survey team takes on its critics p6
Raw data should settle arguments over study methods.
Jim Giles
doi:10.1038/446006a
Q&A: Ronald Plasterk p7
Introducing the Netherlands' new research minister.
doi:10.1038/446007a
Meet the human metabolome p8
Can body fluids succeed where genomics and proteomics have failed?
Helen Pearson
doi:10.1038/446008a
Letting the light in on Antarctic ecosystems p9
Ice-shelf collapse offers glimpse of life beneath the South Pole.
Lucy Odling-Smee
doi:10.1038/446009a
The lab that asked the wrong questions p10
Closure of parapsychology lab throws spotlight on scientific taboos.
Lucy Odling-Smee
doi:10.1038/446010a
Data sharing: the next generation p10
Social software offers fresh perspectives on results.
Declan Butler
doi:10.1038/446010b
Sidelines p11
doi:10.1038/446011a
Scientists rethink approach to HIV gels p12
Tough decisions follow failure of clinical trial.
Erika Check
doi:10.1038/446012a
Trio of studies makes headway in HIV battle p12
Techniques to curb transmission offer hope in fight against AIDS.
Erika Check
doi:10.1038/446012b
Business
A merger too far? p15
Bristol-Myers Squibb has been stoking its research productivity. Meredith Wadman investigates whether an acquisition would be the right prescription for the company.
doi:10.1038/446015a
News Features
Laser physics: Extreme light p16
Physicists are planning lasers powerful enough to rip apart the fabric of space and time. Ed Gerstner is impressed.
doi:10.1038/446016a
See also: Editor's summary
Science of hair: The roots of accomplishment p20
From a New Jersey beauty parlour to cutting-edge genetics by way of her own alopecia, Angela Christiano's life has all been tied up with hair. Helen Pearson meets a woman whose head is full of the stuff that covers it.
doi:10.1038/446020a
Business Feature
Radar satellites: Mountains to molehills p22
As radar satellites reach ever higher resolutions, they are exciting both scientists and the military. Can they make money too? Quirin Schiermeier reports.
Quirin Schiermeier
doi:10.1038/446022a
Correspondence
Potential downsides of perfect pain relief p24
Andrew Mannes and Michael Iadarola
doi:10.1038/446024a
Need to distinguish science (good or bad) from ethics p24
David Campbell
doi:10.1038/446024b
Never mind the footprint, get the mass right p24
Paul Jarvis
doi:10.1038/446024c
Books and Arts
Into the darkness p25
Cosmologists face some tough challenges as they explore the composition of the Universe.
Volker Springel reviews Dark Cosmos: In Search of our Universe's Missing Mass and Energy by Dan Hooper
doi:10.1038/446025a
The roots of complex problems p26
Timothy Gowers reviews Fearless Symmetry: Exposing the Hidden Patterns of Numbers by Avner Ash and Robert Gross
doi:10.1038/446026a
New in Paperback p26
doi:10.1038/446026b
Fascinating rhythm p27
Mayank Mehta reviews Rhythms of the Brain by György Buzsáki
doi:10.1038/446027a
Essay
ConnectionsProtecting biostructure p29
Biodiversity researchers have focused on diversity at the cost of ignoring the networks of interactions between organisms that characterize ecosystems.
Kevin McCann
doi:10.1038/446029a
See also: Editor's summary
News and Views
Physics: Gravity passes a little test p31
Newton's gravity, that old classical warhorse, is well established on scales as large as the Solar System. The latest experimental confirmation of its validity is tiny in scale, but big in implications.
Clive Speake
doi:10.1038/446031a
Physiology: Legacy of leaky channels p32
Mutations that affect the opening and closing of ion channels in cell membranes are associated with disease. Defects in other properties of these channels can also cause ion leakage, with equally devastating consequences.
Richard Horn
doi:10.1038/446032a
See also: Editor's summary
50 & 100 Years Ago p34
doi:10.1038/446034a
Microscopy: Atomic fingerprinting p34
Atomic force microscopy is a well-established technique to image all kinds of surfaces at the atomic scale. But the force patterns that emerge can also pin down the chemical identity of individual atoms.
Alexander Shluger and Tom Trevethan
doi:10.1038/446034b
See also: Editor's summary
Virology: Holed up in a natural crystal p35
Insect viruses that cause polyhedrosis produce infectious microcrystals within a cell. These inclusions were used in a study that pushed the state of the crystallographic art to explain their exceptional stability.
Felix A. Rey
doi:10.1038/446035a
See also: Editor's summary
Materials science: Flaky research p36
Liesbeth Venema
doi:10.1038/446036a
See also: Editor's summary
Photonics: Light localized on the lattice p37
Photonic lattices are materials specially designed to cage light. By shaking the mesh of the cage, we can see how light, initially passing freely, finds its room for manoeuvre progressively restricted.
Z. Valy Vardeny and Mikhail Raikh
doi:10.1038/446037a
See also: Editor's summary
Cell biology: Aneuploidy and cancer p38
Aneuploidy is the condition in which a cell has extra or missing chromosomes, and is often associated with tumours. But whether it is a cause or a consequence of cancer remains a vexed question.
David Pellman
doi:10.1038/446038a
Brief Communications Arising
Climate modelling: Uncertainty in climate-sensitivity estimates pE1
Tapio Schneider
doi:10.1038/nature05707
First paragraph | Full Text | PDF (94K)
Climate modelling: Uncertainty in climate-sensitivity estimates (Reply) pE2
Gabriele C. Hegerl, Thomas J. Crowley, William T. Hyde and David J. Frame
doi:10.1038/nature05708
First paragraph | Full Text | PDF (94K)
Articles
CD38 is critical for social behaviour by regulating oxytocin secretion p41
Duo Jin, Hong-Xiang Liu, Hirokazu Hirai, Takashi Torashima, Taku Nagai, Olga Lopatina, Natalia A. Shnayder, Kiyofumi Yamada, Mami Noda, Toshihiro Seike, Kyota Fujita, Shin Takasawa, Shigeru Yokoyama, Keita Koizumi, Yoshitake Shiraishi, Shigenori Tanaka, Minako Hashii, Toru Yoshihara, Kazuhiro Higashida, Mohammad Saharul Islam, Nobuaki Yamada, Kenshi Hayashi, Naoya Noguchi, Ichiro Kato, Hiroshi Okamoto, Akihiro Matsushima, Alla Salmina, Toshio Munesue, Nobuaki Shimizu, Sumiko Mochida, Masahide Asano and Haruhiro Higashida
doi:10.1038/nature05526
Abstract | Full Text | PDF (949K) | Supplementary information
See also: Editor's summary
MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast p46
Saurabh Paliwal, Pablo A. Iglesias, Kyle Campbell, Zoe Hilioti, Alex Groisman and Andre Levchenko
doi:10.1038/nature05561
Abstract | Full Text | PDF (572K) | Supplementary information
Letters
Transport and Anderson localization in disordered two-dimensional photonic lattices p52
Tal Schwartz, Guy Bartal, Shmuel Fishman and Mordechai Segev
doi:10.1038/nature05623
First paragraph | Full Text | PDF (516K) | Supplementary information
See also: Editor's summary | News and Views by Vardeny & Raikh
Bipolar supercurrent in graphene p56
Hubert B. Heersche, Pablo Jarillo-Herrero, Jeroen B. Oostinga, Lieven M. K. Vandersypen and Alberto F. Morpurgo
doi:10.1038/nature05555
First paragraph | Full Text | PDF (982K) | Supplementary information
See also: Editor's summary | News and Views by Venema
The structure of suspended graphene sheets p60
Jannik C. Meyer, A. K. Geim, M. I. Katsnelson, K. S. Novoselov, T. J. Booth and S. Roth
doi:10.1038/nature05545
First paragraph | Full Text | PDF (1,027K) | Supplementary information
See also: Editor's summary
Chemical identification of individual surface atoms by atomic force microscopy p64
Yoshiaki Sugimoto, Pablo Pou, Masayuki Abe, Pavel Jelinek, Rubén Pérez, Seizo Morita and Óscar Custance
doi:10.1038/nature05530
First paragraph | Full Text | PDF (1,043K) | Supplementary information
See also: Editor's summary | News and Views by Shluger & Trevethan
Implications for plastic flow in the deep mantle from modelling dislocations in MgSiO3 minerals p68
Philippe Carrez, Denise Ferré and Patrick Cordier
doi:10.1038/nature05593
First paragraph | Full Text | PDF (3,437K) | Supplementary information
A topographic map of recruitment in spinal cord p71
David L. McLean, Jingyi Fan, Shin-ichi Higashijima, Melina E. Hale and Joseph R. Fetcho
doi:10.1038/nature05588
First paragraph | Full Text | PDF (952K) | Supplementary information
See also: Editor's summary
Gating pore current in an inherited ion channelopathy p76
Stanislav Sokolov, Todd Scheuer and William A. Catterall
doi:10.1038/nature05598
First paragraph | Full Text | PDF (791K) | Supplementary information
See also: Editor's summary | News and Views by Horn
Chemical rescue of cleft palate and midline defects in conditional GSK-3
mice p79
Karen J. Liu, Joseph R. Arron, Kryn Stankunas, Gerald R. Crabtree and Michael T. Longaker
doi:10.1038/nature05557
First paragraph | Full Text | PDF (969K) | Supplementary information
See also: Editor's summary
In vivo imaging of germinal centres reveals a dynamic open structure p83
Tanja A. Schwickert, Randall L. Lindquist, Guy Shakhar, Geulah Livshits, Dimitris Skokos, Marie H. Kosco-Vilbois, Michael L. Dustin and Michel C. Nussenzweig
doi:10.1038/nature05573
First paragraph | Full Text | PDF (1,630K) | Supplementary information
Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum p88
Heather J. Painter, Joanne M. Morrisey, Michael W. Mather and Akhil B. Vaidya
doi:10.1038/nature05572
First paragraph | Full Text | PDF (334K) | Supplementary information
See also: Editor's summary
Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses p92
Sheli R. Radoshitzky, Jonathan Abraham, Christina F. Spiropoulou, Jens H. Kuhn, Dan Nguyen, Wenhui Li, Jane Nagel, Paul J. Schmidt, Jack H. Nunberg, Nancy C. Andrews, Michael Farzan and Hyeryun Choe
doi:10.1038/nature05539
First paragraph | Full Text | PDF (680K) | Supplementary information
See also: Editor's summary
The molecular organization of cypovirus polyhedra p97
Fasséli Coulibaly, Elaine Chiu, Keiko Ikeda, Sascha Gutmann, Peter W. Haebel, Clemens Schulze-Briese, Hajime Mori and Peter Metcalf
doi:10.1038/nature05628
First paragraph | Full Text | PDF (1,456K) | Supplementary information
See also: Editor's summary | News and Views by Rey
Erratum
Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages p102
Kohki Kawane, Mayumi Ohtani, Keiko Miwa, Takuji Kizawa, Yoshiyuki Kanbara, Yoshichika Yoshioka, Hideki Yoshikawa and Shigekazu Nagata
doi:10.1038/nature05581
Addendum
Artificial 'spin ice' in a geometrically frustrated lattice of nanoscale ferromagnetic islands p102
R. F. Wang, C. Nisoli, R. S. Freitas, J. Li, W. McConville, B. J. Cooley, M. S. Lund, N. Samarth, C. Leighton, V. H. Crespi and P. Schiffer
doi:10.1038/nature05607
Corrigenda
A Mesozoic gliding mammal from northeastern China p102
Jin Meng, Yaoming Hu, Yuanqing Wang, Xiaolin Wang and Chuankui Li
doi:10.1038/nature05639
Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis p102
Sonya S. Glasson, Roger Askew, Barbara Sheppard, Brenda Carito, Tracey Blanchet, Hak-Ling Ma, Carl R. Flannery, Diane Peluso, Kim Kanki, Zhiyong Yang, Manas K. Majumdar and Elisabeth A. Morris
doi:10.1038/nature05640
Genetically modified Plasmodium parasites as a protective experimental malaria vaccine p102
A. K. Mueller, M. Labaied, S. Kappe and K. Matuschewski
doi:10.1038/nature05642
Erratum
Fish can infer social rank by observation alone p102
Logan Grosenick, Tricia S. Clement and Russell D. Fernald
doi:10.1038/nature05646
Naturejobs
ProspectProspects p103
Origami expert illustrates the power of creative transformation.
Paul Smaglik
doi:10.1038/nj7131-103a
Special Report
Getting in the frame p104
The conditions for framework funding are complex and the competition is tough, says Nora Eichinger. But many find the prize is worth the effort.
Nora Eichinger
doi:10.1038/nj7131-104a
Career Views
Tim de Zeeuw, director-general, European Southern Observatory, Garching, Germany p106
Astronomy goes from theories of galaxy shapes to realities of observatory management.
Virginia Gewin
doi:10.1038/nj7131-106a
Hub of alternative energy p106
BP's Energy Biosciences Institute brings jobs and research opportunities to Berkeley.
Virginia Gewin
doi:10.1038/nj7131-106b
On resilience p106
Postodc takes time to tie her shoelaces.
Maria Ocampo-Hafalla
doi:10.1038/nj7131-106c
Recruiters
The inside track from academia and industry: Temporary display p108
If you look on short-term employment as a way of window shopping, you could get a bargain.
Martin Lang
doi:10.1038/nj7131-108a
Highlights
Highlight: European Opportunities
doi:10.1038/nj0147
Opportunities: The National Institutes of Health
doi:10.1038/nj0148
