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Nature 445, 874-880 (22 February 2007) | doi:10.1038/nature05664; Published online 21 February 2007
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John Innes Centre Project Leader in Plant or Microbial Sciences
- University of East Anglia
- Norwich, NR4 7TJ, UK
Head-Preclinical
- Syngene International
- Bangalore, Karnataka 560099 India
Review Article Progress and opportunities for tissue-engineered skin
Sheila MacNeil1
Abstract
Tissue-engineered skin is now a reality. For patients with extensive full-thickness burns, laboratory expansion of skin cells to achieve barrier function can make the difference between life and death, and it was this acute need that drove the initiation of tissue engineering in the 1980s. A much larger group of patients have ulcers resistant to conventional healing, and treatments using cultured skin cells have been devised to restart the wound-healing process. In the laboratory, the use of tissue-engineered skin provides insight into the behaviour of skin cells in healthy skin and in diseases such as vitiligo, melanoma, psoriasis and blistering disorders.
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