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Nature 445, 866-873 (22 February 2007) | doi:10.1038/nature05663; Published online 21 February 2007
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Assistant Professor and Associate Professor
- Massachusetts General Hospital/ Harvard Medical School
- Charlestown, MA
Faculty - Plant Cellular & Molecular Biology, Molecular Genetics & the Plant Molecular Biology / Biotechnology Program
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- Columbus, Ohio
Review Article Pathogenesis and therapy of psoriasis
Michelle A. Lowes1, Anne M. Bowcock2 & James G. Krueger1
Abstract
Psoriasis is one of the most common human skin diseases and is considered to have key genetic underpinnings. It is characterized by excessive growth and aberrant differentiation of keratinocytes, but is fully reversible with appropriate therapy. The trigger of the keratinocyte response is thought to be activation of the cellular immune system, with T cells, dendritic cells and various immune-related cytokines and chemokines implicated in pathogenesis. The newest therapies for psoriasis target its immune components and may predict potential treatments for other inflammatory human diseases.
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NEWS AND VIEWS
Spondyloarthropathies Targeted therapy for psoriatic arthritisNature Reviews Rheumatology News and Views (01 May 2009)
