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Nature 445, 851-857 (22 February 2007) | doi:10.1038/nature05661; Published online 21 February 2007
Open Innovation Challenges
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Efficient Chromosome Doubling: Plant Cell Division
The Seeker is looking for an efficient chromosome doubling method in plants and in particular, metho...
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Protect Enzyme from In Planta Degradation
A proposal for stable expression of an enzyme in corn seed is desired.
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Assistant Physician or Specialist
- University of Dresden, Dept. of Medicine, Director: Prof. S. Bornstein
- Dresden 01307 Germany
Electrophysiologist
- Eisai London Research Laboratories Ltd
- Hatfield, United Kingdom
Review Article Melanoma biology and new targeted therapy
Vanessa Gray-Schopfer1, Claudia Wellbrock1 & Richard Marais1
Abstract
Melanoma is a cancer that arises from melanocytes, specialized pigmented cells that are found predominantly in the skin. The incidence of melanoma is rising steadily in western populations — the number of cases worldwide has doubled in the past 20 years. In its early stages malignant melanoma can be cured by surgical resection, but once it has progressed to the metastatic stage it is extremely difficult to treat and does not respond to current therapies. Recent discoveries in cell signalling have provided greater understanding of the biology that underlies melanoma, and these advances are being exploited to provide targeted drugs and new therapeutic approaches.
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