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Nature 445, 823 (22 February 2007) | doi:10.1038/445823a; Published online 21 February 2007

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John J. Tyson1

  1. John Tyson is university distinguished professor of biological sciences at Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.

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To understand cells as dynamic systems, mathematical tools are needed to fill the gap between molecular interactions and physiological consequences.

Open any issue of Nature and you will find a diagram illustrating the molecular interactions purported to underlie some behaviour of a living cell. The accompanying text explains how the link between molecules and behaviour is thought to be made.