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Bone Metastasis

Can osteoclasts be excluded? (Reply)

Nature volume 445, pages E19–E20 (2007)Cite this article

Abstract

Martin and Mundy1 emphasize the crucial role played by osteoclasts in the metastasis of many tumour types to bone. Our intention was not to question the importance of osteoclasts in bone metastases, but rather to show that RANK ligand (RANKL) exerts additional action on cancer cells beyond its effects on osteoclasts2. We reported that epithelial tumour cells can express RANK, a finding that is supported by earlier work3; that RANKL has chemotactic activity4; and that in vivo inhibition of RANKL by osteoprotegerin reduces tumour burden in bone when assessed in a previously published experimental system5.

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References

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Author information

Authors and Affiliations

  1. *Faculty of Health Sciences, University of Ontario Institute of Technology, Oshawa, Ontario L1H 7K4, Canada,

    D. Holstead Jones

  2. Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, 1030, Austria

    D. Holstead Jones, Tomoki Nakashima, Ivona Kozieradzki, Renu Sarao, Vukoslav Komnenovic, Teiji Wada & Josef M. Penninger

  3. Department of Medical Biophysics, University of Toronto, Toronto, M5G 2C1, Ontario, Canada

    D. Holstead Jones, Ivona Kozieradzki, Evelyn Rubin, Rama Khokha & Josef M. Penninger

  4. Department of Immunology, University of Toronto, Toronto, M5G 2C1, Ontario, Canada

    D. Holstead Jones, Ivona Kozieradzki, Evelyn Rubin & Josef M. Penninger

  5. Ontario Cancer Institute, University Health Network, Toronto, M5G 2C1, Ontario, Canada

    Otto H. Sanchez & Carlo V. Hojilla

  6. ‖Faculty of Dentistry, McGill University, Montreal, Quebec H3A 1A4, Canada,

    Svetlana V. Komarova & Rama Khokha

  7. Amgen Inc., Thousand Oaks, California, 91320-1799, USA

    Ildiko Sarosi & Sean Morony

  8. Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, 790-784, South Korea

    Young-Yun Kong

  9. Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, 1090, Austria

    Martin Schreiber

  10. Department of Physiology and Pharmacology and Division of Oral Biology, CIHR Group in Skeletal Development and Remodeling, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, N6A 5C1, Ontario, Canada

    S. Jeffrey Dixon & Stephen M. Sims

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  1. D. Holstead Jones
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  2. Tomoki Nakashima
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  8. Evelyn Rubin
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  9. Renu Sarao
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  11. Vukoslav Komnenovic
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  12. Young-Yun Kong
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  13. Martin Schreiber
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  14. S. Jeffrey Dixon
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  15. Stephen M. Sims
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  16. Rama Khokha
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  17. Teiji Wada
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  18. Josef M. Penninger
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Jones, D., Nakashima, T., Sanchez, O. et al. Can osteoclasts be excluded? (Reply). Nature 445, E19–E20 (2007). https://doi.org/10.1038/nature05658

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