Table of contents
Volume 445 Number 7129 pp683-794
(this content only available online) indicates content that is available online only
Editorials
Indian voices p683
Good policy decisions on science and the environment require sound contributions from official bodies, pressure groups, the media — and scientists themselves.
doi:10.1038/445683a
Food for thought p683
Science needs to be better applied to the US food-safety system.
doi:10.1038/445683b
Methods in full p684
From now on, Nature authors will be able to include more experimental details in their papers.
doi:10.1038/445684a
News
Broad sweep of genome zeroes in on diabetes p688
Gene association studies begin to bear fruit.
Gene Russo
doi:10.1038/445688a
Berkeley's energy deal with BP sparks unease p688
Fears rise about loss of academic freedom.
Rex Dalton
doi:10.1038/445688b
Disputed inquiry clears bubble-fusion engineer p690
Purdue's investigation fails to satisfy critics.
Eugenie Samuel Reich
doi:10.1038/445690a
Key biology databases go wiki p691
Collaborative approach aims to keep pace with discoveries.
Jim Giles
doi:10.1038/445691a
Norway unveils design of 'doomsday' seed bank p693
Arctic storage site will hold 1.5 million crop strains.
Michael Hopkin
doi:10.1038/445693a
Sidelines p693
doi:10.1038/445693b
Physicists pitch biggest accelerator p694
Plan sets price-tag for next-generation collider.
Geoff Brumfiel
doi:10.1038/445694a
Pigments help to date disputed masterpiece p695
Spectroscopy puts painting in the Renaissance.
Alison Abbott
doi:10.1038/445695a
News in brief p697
doi:10.1038/445697a
Correction p697
doi:10.1038/445697b
Column
Party of oneA word in the right place p698
Lobbyists give an impetus to causes that can offer a significant advantage on Capitol Hill. But how do they go about getting their way? David Goldston examines their role in securing science funding.
David Goldston
doi:10.1038/445698a
Business
France strives for sharper image p699
As US biotechnology companies seek to expand or relocate their operations abroad, Paris is pitching itself as a scientifically strategic location. Rex Dalton reports.
doi:10.1038/445699a
News Features
Scientists in love: When two worlds collide p700
One half of a physics couple that met online, Jennifer Ouellette seeks some advice from married scientists on how to handle both long-distance and up-close relationships, while juggling career and family. Can love survive?
doi:10.1038/445700a
See also: Editor's summary
Food chains: Killer in the kelp p703
Could a change in the dining habits of orcas crash an ecosystem? Mark Schrope reports on a mystery that reveals how little we know of the oceans.
doi:10.1038/445703a
See also: Editor's summary
India's watchdog: A breath of fresh air p706
How often does independent research change laws as well as minds? A lobby group in Delhi is forcing the Indian government into new regulations. Apoorva Mandavilli meets its leader.
doi:10.1038/445706a
Correspondence
US air pollution is harmful and fine particles can kill p709
Steve Moorhouse
doi:10.1038/445709a
Quality evaluation needs some better quality tools p709
Thomas F. Döring
doi:10.1038/445709b
Fossils: professionals and amateurs can cooperate p709
Nigel Hughes
doi:10.1038/445709c
Ignore the spurious claims of private fossil-hoarders p709
Jean-Louis Hartenberger
doi:10.1038/445709d
Books and Arts
Choose your own reward p711
Does human creativity stem from a process that turns arbitrary ideas into goals like food and sex?
Andy Clark reviews Why Choose This Book? How We Make Decisions by Read Montague
doi:10.1038/445711a
See also: Editor's summary
Shooting for the Moon p712
Alex Roland reviews The Man Who Ran the Moon: James Webb, JFK, and the Secret History of Project Apollo by Piers Bizony
doi:10.1038/445712a
Opposites attract p713
John Whitfield reviews Measuring the World by Daniel Kehlmann
doi:10.1038/445713a
Science in culture: The molecular landscape p714
Lucia Covi uses modern microscopy to highlight the world at the nanoscale.
Martin Kemp
doi:10.1038/445714a
Essay
ConnectionsCollective minds p715
By tapping into social cues, individuals in a group may gain access to higher-order computational capacities that mirror the group's responses to its environment.
Iain Couzin
doi:10.1038/445715a
See also: Editor's summary
News and Views
Conservation biology: The diversity of biodiversity p717
Species richness is not the same as evolutionary richness. So which is the better measure for setting conservation priorities? The flora of the Cape of South Africa provides a test for that pressing question.
Arne Ø. Mooers
doi:10.1038/445717a
See also: Editor's summary
Analytical chemistry: Sense and versatility p718
Molecules that detect chemicals are the workhorses of analytical devices, but most recognize only one kind of target. A molecular sensor has now been devised that measures the concentrations of several metal ions.
A. Prasanna de Silva
doi:10.1038/445718a
50 & 100 Years Ago p719
doi:10.1038/445719a
Plasma physics: On the crest of a wake p721
What a conventional particle accelerator needs kilometres to achieve, a compact 'plasma wakefield' accelerator has just mastered in less than a metre. So is it adieu to the era of the gargantuan mega-accelerator?
Robert Bingham
doi:10.1038/445721a
See also: Editor's summary
Vascular Biology: Vessel guidance p722
Embryos and tumours use the same signalling pathways to direct the formation of blood vessels. Discovery of a new role for the Notch pathway in that process presents a fresh option for cancer treatment.
Thomas Gridley
doi:10.1038/445722a
Quantum mechanics: The truth about reality p723
Hopes of keeping quantum mechanics 'real' have been dashed by new measurements of neutrons' quantum behaviour. Despite what our classical sensibilities require, the world is indeed fundamentally random.
Gregor Weihs
doi:10.1038/445723a
Developmental biology: Cell fate in the mammary gland p724
Most breast cancers have their origin in the luminal epithelial cells of the mammary gland. Defining how a master regulator controls the development of this cell lineage could provide important hints about why this should be.
Qiang Tong & Gökhan S. Hotamisligil
doi:10.1038/445724a
Nanofluidics: Silicon for the perfect membrane p726
Newly developed ultrathin silicon membranes can filter and separate molecules much more effectively than conventional polymer membranes. Many applications, of economic and medical significance, stand to benefit.
Albert van den Berg & Matthias Wessling
doi:10.1038/445726a
See also: Editor's summary
Brief Communications Arising
Structural Biology: Analysis of 'downhill' protein folding pE14
Neil Ferguson, Timothy D. Sharpe, Christopher M. Johnson, Pamela J. Schartau & Alan R. Fersht
doi:10.1038/nature05643
First paragraph | Full Text | PDF (757K)
Structural Biology: Analysis of protein-folding cooperativity pE16
Zheng Zhou & Yawen Bai
doi:10.1038/nature05644
First paragraph | Full Text | PDF (834K)
Structural Biology: Analysis of 'downhill' protein folding; Analysis of protein-folding cooperativity (Reply) pE17
Mourad Sadqi, David Fushman & Victor Muñoz
doi:10.1038/nature05645
First paragraph | Full Text | PDF (333K)
Articles
The architecture of human kin detection p727
Debra Lieberman, John Tooby & Leda Cosmides
doi:10.1038/nature05510
Abstract | Full Text | PDF (222K) | Supplementary information
See also: Editor's summary
Structural definition of a conserved neutralization epitope on HIV-1 gp120 p732
Tongqing Zhou, Ling Xu, Barna Dey, Ann J. Hessell, Donald Van Ryk, Shi-Hua Xiang, Xinzhen Yang, Mei-Yun Zhang, Michael B. Zwick, James Arthos, Dennis R. Burton, Dimiter S. Dimitrov, Joseph Sodroski, Richard Wyatt, Gary J. Nabel & Peter D. Kwong
doi:10.1038/nature05580
Abstract | Full Text | PDF (696K) | Supplementary information
See also: Editor's summary
Letters
Early gas stripping as the origin of the darkest galaxies in the Universe p738
L. Mayer, S. Kazantzidis, C. Mastropietro & J. Wadsley
doi:10.1038/nature05552
First paragraph | Full Text | PDF (287K) | Supplementary information
See also: Editor's summary
Energy doubling of 42 GeV electrons in a metre-scale plasma wakefield accelerator p741
Ian Blumenfeld, Christopher E. Clayton, Franz-Josef Decker, Mark J. Hogan, Chengkun Huang, Rasmus Ischebeck, Richard Iverson, Chandrashekhar Joshi, Thomas Katsouleas, Neil Kirby, Wei Lu, Kenneth A. Marsh, Warren B. Mori, Patric Muggli, Erdem Oz, Robert H. Siemann, Dieter Walz & Miaomiao Zhou
doi:10.1038/nature05538
First paragraph | Full Text | PDF (309K) | Supplementary information
See also: Editor's summary | News and Views by Bingham
Ultralow-power organic complementary circuits p745
Hagen Klauk, Ute Zschieschang, Jens Pflaum & Marcus Halik
doi:10.1038/nature05533
First paragraph | Full Text | PDF (329K) | Supplementary information
See also: Editor's summary
Charge- and size-based separation of macromolecules using ultrathin silicon membranes p749
Christopher C. Striemer, Thomas R. Gaborski, James L. McGrath & Philippe M. Fauchet
doi:10.1038/nature05532
First paragraph | Full Text | PDF (686K) | Supplementary information
See also: Editor's summary | News and Views by van den Berg & Wessling
The Earth's 'hum' is driven by ocean waves over the continental shelves p754
Spahr C. Webb
doi:10.1038/nature05536
First paragraph | Full Text | PDF (334K) | Supplementary information
See also: Editor's summary
Preserving the evolutionary potential of floras in biodiversity hotspots p757
Félix Forest,
Richard Grenyer,
Mathieu Rouget,
T. Jonathan Davies,
Richard M. Cowling,
Daniel P. Faith,
Andrew Balmford,
John C. Manning,
erban Proche
,
Michelle van der Bank,
Gail Reeves,
Terry A. J. Hedderson
&
Vincent Savolainen
doi:10.1038/nature05587
First paragraph | Full Text | PDF (461K) | Supplementary information
See also: Editor's summary | News and Views by Mooers
Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice p761
Yuichi Wakabayashi, Jian-Hua Mao, Ken Brown, Michael Girardi & Allan Balmain
doi:10.1038/nature05489
First paragraph | Full Text | PDF (735K) | Supplementary information
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression p766
Yisong Y. Wan & Richard A. Flavell
doi:10.1038/nature05479
First paragraph | Full Text | PDF (706K) | Supplementary information
Foxp3-dependent programme of regulatory T-cell differentiation p771
Marc A. Gavin, Jeffrey P. Rasmussen, Jason D. Fontenot, Valeria Vasta, Vincent C. Manganiello, Joseph A. Beavo & Alexander Y. Rudensky
doi:10.1038/nature05543
First paragraph | Full Text | PDF (466K) | Supplementary information
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis p776
Mats Hellström, Li-Kun Phng, Jennifer J. Hofmann, Elisabet Wallgard, Leigh Coultas, Per Lindblom, Jackelyn Alva, Ann-Katrin Nilsson, Linda Karlsson, Nicholas Gaiano, Keejung Yoon, Janet Rossant, M. Luisa Iruela-Arispe, Mattias Kalén, Holger Gerhardt & Christer Betsholtz
doi:10.1038/nature05571
First paragraph | Full Text | PDF (2,232K) | Supplementary information
See also: News and Views by Gridley
Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries p781
Arndt F. Siekmann & Nathan D. Lawson
doi:10.1038/nature05577
First paragraph | Full Text | PDF (802K) | Supplementary information
See also: News and Views by Gridley
Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase p785
Ya-Chieh Hsu, Joshua J. Chern, Yi Cai, Mingyao Liu & Kwang-Wook Choi
doi:10.1038/nature05528
First paragraph | Full Text | PDF (1,037K) | Supplementary information
See also: Editor's summary
Naturejobs
ProspectMedia publicity for science can be a double-edged sword. p789
Paul Smaglik
doi:10.1038/nj7129-789a
Region
Georgia on the mind p790
Increasing investment in people is raising the Atlanta region's profile — and attracting a stream of internationally acclaimed researchers. Paul Smaglik reports.
Paul Smaglik
doi:10.1038/nj7129-790a
Career Views
Bertil Andersson, Provost, Nanyang Technological University, Singapore p792
Bertil Andersson leaves the European Science Foundation for Singapore.
Virginia Gewin
doi:10.1038/nj7129-792a
Goodbye Poland, again p792
Poland must do a better job at retaining talent and nurturing science.
Arkadiusz Szklarczyk
doi:10.1038/nj7129-792b
Taking a gamble p792
The challenge of changing research areas and continents.
Chris Rowan
doi:10.1038/nj7129-792c
Recruitment
Crime scene investigators p794
Forensic science is swamped with applicants, but a pure science degree will put you ahead of the crowd.
Richard Smith
doi:10.1038/nj7129-794a
Spotlight
Spotlight on Georgia
doi:10.1038/nj0145
Highlights
Opportunities: The National Institutes of Health
doi:10.1038/nj0146