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Structural Biology

Analysis of 'downhill' protein folding; Analysis of protein-folding cooperativity (Reply)

Nature volume 445, pages E17–E18 (2007)Cite this article

Abstract

Ferguson et al.1 and Zhou and Bai2 criticize the quality of our nuclear magnetic resonance (NMR) data and atom-by-atom analysis of global 'downhill' folding3, also claiming that the data are compatible with two-state folding.

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Figure 1: Analysis of the physical relevance of global two-state fits.

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References

  1. Ferguson, N., Sharpe, T. D., Johnson, C. M., Schartau, P. J. & Fersht, A. R. Nature 445, doi: 10.1038/nature05643 (2007).

  2. Zhou, Z. & Bai, Y. Nature 445, doi: 10.1038/nature05644 (2007).

  3. Sadqi, M., Fushman, D. & Muñoz, V. Nature 442, 317–321 (2006).

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  4. Ferguson, N. et al. J. Mol. Biol. 353, 427–446 (2005).

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  5. Naganathan, A. N., Perez-Jimenez, R., Sanchez-Ruiz, J. M. & Muñoz, V. Biochemistry 44, 7435–7449 (2005).

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, and Center for Biomolecular Structure and Organization, University of Maryland, College Park, 20742, Maryland, USA

    Mourad Sadqi, David Fushman & Victor Muñoz

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  1. Mourad Sadqi
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  2. David Fushman
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  3. Victor Muñoz
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Sadqi, M., Fushman, D. & Muñoz, V. Analysis of 'downhill' protein folding; Analysis of protein-folding cooperativity (Reply). Nature 445, E17–E18 (2007). https://doi.org/10.1038/nature05645

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