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Nature 445, E17-E18 (15 February 2007) | doi:10.1038/nature05645; Published online 14 February 2007

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Structural Biology: Analysis of 'downhill' protein folding; Analysis of protein-folding cooperativity (Reply)

Mourad Sadqi1, David Fushman1 & Victor Muñoz1

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Ferguson et al.1 and Zhou and Bai2 criticize the quality of our nuclear magnetic resonance (NMR) data and atom-by-atom analysis of global 'downhill' folding3, also claiming that the data are compatible with two-state folding.

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Structural biology Proteins downhill all the way

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