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News and Views
Nature 445, 722-723 (15 February 2007) | doi:10.1038/445722a; Published online 14 February 2007
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Vascular Biology: Vessel guidance
Thomas Gridley1
Abstract
Embryos and tumours use the same signalling pathways to direct the formation of blood vessels. Discovery of a new role for the Notch pathway in that process presents a fresh option for cancer treatment.
Angiogenesis, the growth of new blood vessels from existing ones, is a highly active process in embryos. In adults, blood vessels in most organs are quiescent — except, notably, during the growth of solid tumours, when embryonic signalling pathways direct new blood vessels to grow around and into the tumour.
- Thomas Gridley is at The Jackson Laboratory,
Bar Harbor, Maine 04609, USA.
Email: tom.gridley@jax.org
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