TY - JOUR AU - Hanahan, D. AU - Weinberg, R. A. TI - The hallmarks of cancer JA - Cell PY - 2000/// VL - 100 SP - 57 EP - 70 PB - Nature Publishing Group M3 - 10.1016/S0092-8674(00)81683-9 N1 - 10.1016/S0092-8674(00)81683-9 UR - http://dx.doi.org/10.1016/S0092-8674(00)81683-9 ER - TY - JOUR AU - Chin, L. TI - Essential role for oncogenic Ras in tumour maintenance JA - Nature PY - 1999/// VL - 400 SP - 468 EP - 472 PB - Nature Publishing Group M3 - 10.1038/22788 N1 - 10.1038/22788 UR - http://dx.doi.org/10.1038/22788 ER - TY - JOUR AU - Jain, M. TI - Sustained loss of a neoplastic phenotype by brief inactivation of MYC JA - Science PY - 2002/// VL - 297 SP - 102 EP - 104 PB - Nature Publishing Group M3 - 10.1126/science.1071489 N1 - 10.1126/science.1071489 UR - http://dx.doi.org/10.1126/science.1071489 ER - TY - JOUR AU - Fisher, G. H. TI - Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes JA - Genes Dev. PY - 2001/// VL - 15 SP - 3249 EP - 3262 PB - Nature Publishing Group M3 - 10.1101/gad.947701 N1 - 10.1101/gad.947701 UR - http://dx.doi.org/10.1101/gad.947701 ER - TY - JOUR AU - Pelengaris, S. AU - Khan, M. AU - Evan, G. I. TI - Suppression of Myc-induced apoptosis in [bgr] cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression JA - Cell PY - 2002/// VL - 109 SP - 321 EP - 334 PB - Nature Publishing Group M3 - 10.1016/S0092-8674(02)00738-9 N1 - 10.1016/S0092-8674(02)00738-9 UR - http://dx.doi.org/10.1016/S0092-8674(02)00738-9 ER - TY - JOUR AU - Weinstein, I. B. TI - Cancer. Addiction to oncogenes-the Achilles heel of cancer JA - Science PY - 2002/// VL - 297 SP - 63 EP - 64 PB - Nature Publishing Group M3 - 10.1126/science.1073096 N1 - 10.1126/science.1073096 UR - http://dx.doi.org/10.1126/science.1073096 ER - TY - JOUR AU - Druker, B. J. TI - Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia JA - N. Engl. J. Med. PY - 2001/// VL - 344 SP - 1031 EP - 1037 PB - Nature Publishing Group M3 - 10.1056/NEJM200104053441401 N1 - 10.1056/NEJM200104053441401 UR - http://dx.doi.org/10.1056/NEJM200104053441401 ER - TY - JOUR AU - Demetri, G. D. TI - Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors JA - N. Engl. J. Med. PY - 2002/// VL - 347 SP - 472 EP - 480 PB - Nature Publishing Group M3 - 10.1056/NEJMoa020461 N1 - 10.1056/NEJMoa020461 UR - http://dx.doi.org/10.1056/NEJMoa020461 ER - TY - JOUR AU - Lynch, T. J. TI - Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib JA - N. Engl. J. Med. PY - 2004/// VL - 350 SP - 2129 EP - 2139 PB - Nature Publishing Group M3 - 10.1056/NEJMoa040938 N1 - 10.1056/NEJMoa040938 UR - http://dx.doi.org/10.1056/NEJMoa040938 ER - TY - JOUR AU - Paez, J. G. TI - EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy JA - Science PY - 2004/// VL - 304 SP - 1497 EP - 1500 PB - Nature Publishing Group M3 - 10.1126/science.1099314 N1 - 10.1126/science.1099314 UR - http://dx.doi.org/10.1126/science.1099314 ER - TY - JOUR AU - Sherr, C. J. TI - Principles of tumor suppression JA - Cell PY - 2004/// VL - 116 SP - 235 EP - 246 PB - Nature Publishing Group M3 - 10.1016/S0092-8674(03)01075-4 N1 - 10.1016/S0092-8674(03)01075-4 UR - http://dx.doi.org/10.1016/S0092-8674(03)01075-4 ER - TY - JOUR AU - Olivier, M. TI - The IARC TP53 database: new online mutation analysis and recommendations to users JA - Hum. Mutat. PY - 2002/// VL - 19 SP - 607 EP - 614 PB - Nature Publishing Group M3 - 10.1002/humu.10081 N1 - 10.1002/humu.10081 UR - http://dx.doi.org/10.1002/humu.10081 ER - TY - JOUR AU - Bykov, V. J. TI - Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound JA - Nature Med. PY - 2002/// VL - 8 SP - 282 EP - 288 PB - Nature Publishing Group M3 - 10.1038/nm0302-282 N1 - 10.1038/nm0302-282 UR - http://dx.doi.org/10.1038/nm0302-282 ER - TY - JOUR AU - Snyder, E. L. AU - Meade, B. R. AU - Saenz, C. C. AU - Dowdy, S. F. TI - Treatment of terminal peritoneal carcinomatosis by a transducible p53-activating peptide JA - PLoS Biol. PY - 2004/// VL - 2 SP - E36 PB - Nature Publishing Group M3 - 10.1371/journal.pbio.0020036 N1 - 10.1371/journal.pbio.0020036 UR - http://dx.doi.org/10.1371/journal.pbio.0020036 ER - TY - JOUR AU - Branda, C. S. AU - Dymecki, S. M. TI - Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice JA - Dev. Cell PY - 2004/// VL - 6 SP - 7 EP - 28 PB - Nature Publishing Group M3 - 10.1016/S1534-5807(03)00399-X N1 - 10.1016/S1534-5807(03)00399-X UR - http://dx.doi.org/10.1016/S1534-5807(03)00399-X ER - TY - JOUR AU - Donehower, L. A. TI - Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours JA - Nature PY - 1992/// VL - 356 SP - 215 EP - 221 PB - Nature Publishing Group M3 - 10.1038/356215a0 N1 - 10.1038/356215a0 UR - http://dx.doi.org/10.1038/356215a0 ER - TY - JOUR AU - Jacks, T. TI - Tumor spectrum analysis in p53-mutant mice JA - Curr. Biol. PY - 1994/// VL - 4 SP - 1 EP - 7 PB - Nature Publishing Group M3 - 10.1016/S0960-9822(00)00002-6 N1 - 10.1016/S0960-9822(00)00002-6 UR - http://dx.doi.org/10.1016/S0960-9822(00)00002-6 ER - TY - JOUR AU - Indra, A. K. TI - Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ERT and Cre-ERT2 recombinases JA - Nucleic Acids Res. PY - 1999/// VL - 27 SP - 4324 EP - 4327 PB - Nature Publishing Group M3 - 10.1093/nar/27.22.4324 N1 - 10.1093/nar/27.22.4324 UR - http://dx.doi.org/10.1093/nar/27.22.4324 ER - TY - JOUR AU - Soriano, P. TI - Generalized lacZ expression with the ROSA26 Cre reporter strain JA - Nature Genet. PY - 1999/// VL - 21 SP - 70 EP - 71 PB - Nature Publishing Group M3 - 10.1038/5007 N1 - 10.1038/5007 UR - http://dx.doi.org/10.1038/5007 ER - TY - JOUR AU - Kemp, C. J. AU - Wheldon, T. AU - Balmain, A. TI - p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis JA - Nature Genet. PY - 1994/// VL - 8 SP - 66 EP - 69 PB - Nature Publishing Group M3 - 10.1038/ng0994-66 N1 - 10.1038/ng0994-66 UR - http://dx.doi.org/10.1038/ng0994-66 ER - TY - JOUR AU - Collado, M. TI - Tumour biology: senescence in premalignant tumours JA - Nature PY - 2005/// VL - 436 SP - 642 PB - Nature Publishing Group M3 - 10.1038/436642a N1 - 10.1038/436642a UR - http://dx.doi.org/10.1038/436642a ER - TY - JOUR AU - Lowe, S. W. AU - Sherr, C. J. TI - Tumor suppression by Ink4a-Arf: progress and puzzles JA - Curr. Opin. Genet. Dev. PY - 2003/// VL - 13 SP - 77 EP - 83 PB - Nature Publishing Group M3 - 10.1016/S0959-437X(02)00013-8 N1 - 10.1016/S0959-437X(02)00013-8 UR - http://dx.doi.org/10.1016/S0959-437X(02)00013-8 ER - TY - JOUR AU - Xue, W. TI - Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas JA - Nature PB - Nature Publishing Group M3 - 10.1038/nature05529 N1 - 10.1038/nature05529 UR - http://dx.doi.org/10.1038/nature05529 ER - TY - JOUR AU - Zhang, L. TI - Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial sarcoma by transcriptional suppression of vascular endothelial growth factor expression JA - Cancer Res. PY - 2000/// VL - 60 SP - 3655 EP - 3661 PB - Nature Publishing Group ER - TY - JOUR AU - Teodoro, J. G. AU - Parker, A. E. AU - Zhu, X. AU - Green, M. R. TI - p53-mediated inhibition of angiogenesis through up-regulation of a collagen prolyl hydroxylase JA - Science PY - 2006/// VL - 313 SP - 968 EP - 971 PB - Nature Publishing Group M3 - 10.1126/science.1126391 N1 - 10.1126/science.1126391 UR - http://dx.doi.org/10.1126/science.1126391 ER - TY - JOUR AU - Dickins, R. A. TI - Probing tumor phenotypes using stable and regulated synthetic microRNA precursors JA - Nature Genet. PY - 2005/// VL - 37 SP - 1289 EP - 1295 PB - Nature Publishing Group M3 - 10.1038/ng1651 N1 - 10.1038/ng1651 UR - http://dx.doi.org/10.1038/ng1651 ER - TY - JOUR AU - Christophorou, M. A. TI - Temporal dissection of p53 function in vitro and in vivo JA - Nature Genet. PY - 2005/// VL - 37 SP - 718 EP - 726 PB - Nature Publishing Group M3 - 10.1038/ng1572 N1 - 10.1038/ng1572 UR - http://dx.doi.org/10.1038/ng1572 ER - TY - JOUR AU - Christophorou, M. A. AU - Ringshausen, I. AU - Finch, A. J. AU - Swigart, L. B. AU - Evan, G. I. TI - The pathological response to DNA damage does not contribute to p53-mediated tumour suppression JA - Nature PY - 2006/// VL - 443 SP - 214 EP - 217 PB - Nature Publishing Group M3 - 10.1038/nature05077 N1 - 10.1038/nature05077 UR - http://dx.doi.org/10.1038/nature05077 ER - TY - JOUR AU - Vassilev, L. T. TI - In vivo activation of the p53 pathway by small-molecule antagonists of MDM2 JA - Science PY - 2004/// VL - 303 SP - 844 EP - 848 PB - Nature Publishing Group M3 - 10.1126/science.1092472 N1 - 10.1126/science.1092472 UR - http://dx.doi.org/10.1126/science.1092472 ER - TY - JOUR AU - Haupt, S. AU - Haupt, Y. TI - Manipulation of the tumor suppressor p53 for potentiating cancer therapy JA - Semin. Cancer Biol. PY - 2004/// VL - 14 SP - 244 EP - 252 PB - Nature Publishing Group M3 - 10.1016/j.semcancer.2004.04.003 N1 - 10.1016/j.semcancer.2004.04.003 UR - http://dx.doi.org/10.1016/j.semcancer.2004.04.003 ER - TY - JOUR AU - Olive, K. P. TI - Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome JA - Cell PY - 2004/// VL - 119 SP - 847 EP - 860 PB - Nature Publishing Group M3 - 10.1016/j.cell.2004.11.004 N1 - 10.1016/j.cell.2004.11.004 UR - http://dx.doi.org/10.1016/j.cell.2004.11.004 ER -