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Nature 445, 661-665 (24 January 2007) | doi:10.1038/nature05541;
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University Full-Professor (W3, Tenure Track)
- University of Münster
- Munster 48149 Germany
Professor of Cognitive Neuroscience
- Karolinska Institute
- Stockholm Sweden
Restoration of p53 function leads to tumour regression in vivo
Tumorigenesis is a multi-step process that requires activation of oncogenes and inactivation of tumour suppressor genes. Mouse models of human cancers have recently demonstrated that continuous expression of a dominantly acting oncogene (for example, Hras, Kras and Myc) is often required for tumour maintenance; this phenotype is referred to as oncogene addiction.
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