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Nature 445, 656-660 (24 January 2007) | doi:10.1038/nature05529;
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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Although cancer arises from a combination of mutations in oncogenes and tumour suppressor genes, the extent to which tumour suppressor gene loss is required for maintaining established tumours is poorly understood. p53 is an important tumour suppressor that acts to restrict proliferation in response to DNA damage or deregulation of mitogenic oncogenes, by leading to the induction of various cell cycle checkpoints, apoptosis or cellular senescence.
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