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Nature 445, 671-675 (31 January 2007) | doi:10.1038/nature05515;
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Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation
DNA methylation is an epigenetic modification that is essential for gene silencing and genome stability in many organisms. Although methyltransferases that promote DNA methylation are well characterized, the molecular mechanism underlying active DNA demethylation is poorly understood and controversial.
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