Table of contents
Volume 445 Number 7128 pp567-675
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Editorials
Light at the end of the tunnel p567
An emphatic and clear status report on global warming opens the way for action — presenting new risks.
doi:10.1038/445567a
See also: Editor's summary
Steady progress p568
Better budgets for biologists.
doi:10.1038/445568a
Welcome home p568
Italian and Spanish researchers returning from abroad deserve more support.
doi:10.1038/445568b
News
Bush and Congress set debate on priorities p572
US science budget is caught in tug-of-war.
Emma Marris, Geoff Brumfiel, Meredith Wadman & Lucy Odling-Smee
doi:10.1038/445572a
Dig links Stonehenge to circle of life p574
Unearthed village offers glimpse of feasts and funerals.
Lucy Odling-Smee
doi:10.1038/445574a
Virus paper reignites prion spat p575
Neuroscientist challenges conventional wisdom on brain disease.
Heidi Ledford
doi:10.1038/445575a
Sidelines p575
doi:10.1038/445575b
Africa pursues goal of scientific unity p576
Summit paves way for broader cooperation.
Ehsan Masood
doi:10.1038/445576a
News
Special Report: From words to action p578
The scientific case for global warming is overwhelming. So what next for the IPCC? Helping policymakers decide what to do now may require radical reform, reports Jim Giles.
doi:10.1038/445578a
See also: Editor's summary
Special Report
Climate change 2007: What They're Saying p579
doi:10.1038/445579a
Climate change 2007: What we don't know about climate change p580
Uncertainty remains over feedback effects.
Quirin Schiermeier
doi:10.1038/445580a
Climate change 2007: Data keep flooding in p581
The studies that came too late for the IPCC report.
Michael Hopkin
doi:10.1038/445581a
Climate change 2007: Climate sceptics switch focus to economics p582
As the scientific case strengthens, dissenters change tack.
Michael Hopkin
doi:10.1038/445582a
Climate change 2007: What price a cooler future? p582
Balancing costs and ethics in the Stern report.
Lucy Odling-Smee
doi:10.1038/445582b
Business
Carbon copies p584
The corridors of power in the United States are ringing with the phrase 'cap and trade'. But when will carbon markets arrive in America — and what will they look like? Emma Marris investigates.
doi:10.1038/445584a
See also: Editor's summary
In brief p585
doi:10.1038/445585a
Market watch p585
Quirin Schiermeier
doi:10.1038/445585b
News Features
Energy efficiency: Super savers: Meters to manage the future p586
Energy efficiency is one of the least flashy but most promising ways to cut carbon dioxide emissions. In the first of two features, Declan Butler explores the energy-saving possibilities of an intelligent electrical grid. In the second, Zoë Corbyn looks at how labs can cut their energy use.
doi:10.1038/445586a
Energy efficiency: Super savers: Experimenting with efficiency p590
doi:10.1038/445590a
Correspondence
How important is immune memory to invertebrates? p593
Simon Fellous
doi:10.1038/445593a
Getting that first scent of life while we're in the womb p593
Andreas Keller
doi:10.1038/445593b
Colour-blindness: how to alienate a grant reviewer p593
Joseph A. Ross
doi:10.1038/445593c
Sherlock Holmes's skills as a philosopher? Elementary p593
Philip Beaman
doi:10.1038/445593d
Commentaries
Is the global carbon market working? p595
The Clean Development Mechanism can be viewed not only as a market, but also as a subsidy and a political mechanism. Michael Wara argues that it has been most effective, so far, in achieving its political goals.
doi:10.1038/445595a
See also: Editor's summary
Climate change 2007: Lifting the taboo on adaptation p597
Renewed attention to policies for adapting to climate change cannot come too soon for Roger Pielke, Jr, Gwyn Prins, Steve Rayner and Daniel Sarewitz.
doi:10.1038/445597a
See also: Editor's summary
Books and Arts
A man of magnitude p599
Charles Richter developed the scale for measuring earthquakes.
Gregory C. Beroza reviews Richter's Scale: Measure of an Earthquake, Measure of a Man by Susan Elizabeth Hough
doi:10.1038/445599a
Unfit for modern life p600
Michael Sargent reviews Mismatch: Why Our World No Longer Fits Our Bodies by Peter Gluckman & Mark Hanson
doi:10.1038/445600a
A big bite of the past p601
doi:10.1038/445601a
Back to basics p601
Bruce H. Weber reviews Darwinian Reductionism: Or, How to Stop Worrying and Love Molecular Biology by Alex Rosenberg
doi:10.1038/445601b
Essay
ConnectionsA clash of two cultures p603
Physicists come from a tradition of looking for all-encompassing laws, but is this the best approach to use when probing complex biological systems?
Evelyn Fox Keller
doi:10.1038/445603a
See also: Editor's summary
News and Views
Quantum physics: Indistinguishable from afar p605
Imprinting a coherent light pulse on the spins of atoms is standard quantum sorcery. Retrieving the same light pulse from a second, distant set of atoms looks rather like black magic. But it, too, is just quantum mechanics.
Michael Fleischhauer
doi:10.1038/445605a
See also: Editor's summary
Cancer biology: Gone but not forgotten p606
The p53 tumour-suppressor protein is a cell's principal guardian against cancer. Most cancers eliminate p53 — but it seems that its pathway remains intact, so resurrecting it might provide a cancer therapy.
Norman E. Sharpless & Ronald A. DePinho
doi:10.1038/nature05567
See also: Editor's summary
Palaeoclimate: When the world turned cold p607
As massive ice sheets grew on Antarctica during the first major glaciation of the Cenozoic era, the northern continents cooled and dried. The coincidence in timing implies that the cause was global rather than regional.
Gabriel J. Bowen
doi:10.1038/445607a
See also: Editor's summary
Structural biology: Molecular machinery in action p609
Nuclear magnetic resonance is the best way to study motion in proteins, but it could be applied only to small systems. This limitation has been overcome to reveal the dynamics of a large protein complex.
Ad Bax & Dennis A. Torchia
doi:10.1038/nature05566
See also: Editor's summary
News and Views Feature
Evolutionary biology: Out of thin air p610
The invention of oxygenic photosynthesis was a small step for a bacterium, but a giant leap for biology and geochemistry. So when and how did cells first learn to split water to make oxygen gas?
John F. Allen & William Martin
doi:10.1038/445610a
See also: Editor's summary
Brief Communications Arising
Veterinary epidemiology: Vaccination strategies for foot-and-mouth disease pE12
Richard P. Kitching, Nicholas M. Taylor & Michael V. Thrusfield
doi:10.1038/nature05604
First paragraph | Full Text | PDF (68K)
Veterinary epidemiology: Vaccination strategies for foot-and-mouth disease (reply) pE12
Michael J. Tildesley, Nicholas J. Savill, Darren J. Shaw, Rob Deardon, Stephen P. Brooks, Mark E. J. Woolhouse, Bryan T. Grenfell & Matt J. Keeling
doi:10.1038/nature05605
First paragraph | Full Text | PDF (74K)
Articles
Axial patterning in cephalochordates and the evolution of the organizer p613
Jr-Kai Yu, Yutaka Satou, Nicholas D. Holland, Tadasu Shin-I, Yuji Kohara, Noriyuki Satoh, Marianne Bronner-Fraser & Linda Z. Holland
doi:10.1038/nature05472
Abstract | Full Text | PDF (684K) | Supplementary information
See also: Editor's summary
Quantitative dynamics and binding studies of the 20S proteasome by NMR p618
Remco Sprangers & Lewis E. Kay
doi:10.1038/nature05512
Abstract | Full Text | PDF (1,187K) | Supplementary information
See also: Editor's summary | News and Views by Bax & Torchia
Letters
Coherent control of optical information with matter wave dynamics p623
Naomi S. Ginsberg, Sean R. Garner & Lene Vestergaard Hau
doi:10.1038/nature05493
First paragraph | Full Text | PDF (553K)
See also: Editor's summary | News and Views by Fleischhauer
Molecular fingerprinting with the resolved modes of a femtosecond laser frequency comb p627
Scott A. Diddams, Leo Hollberg & Vela Mbele
doi:10.1038/nature05524
First paragraph | Full Text | PDF (860K)
Patterning of sodium ions and the control of electrons in sodium cobaltate p631
M. Roger, D. J. P. Morris, D. A. Tennant, M. J. Gutmann, J. P. Goff, J.-U. Hoffmann, R. Feyerherm, E. Dudzik, D. Prabhakaran, A. T. Boothroyd, N. Shannon, B. Lake & P. P. Deen
doi:10.1038/nature05531
First paragraph | Full Text | PDF (764K) | Supplementary information
See also: Editor's summary
Tibetan plateau aridification linked to global cooling at the Eocene–Oligocene transition p635
Guillaume Dupont-Nivet, Wout Krijgsman, Cor G. Langereis, Hemmo A. Abels, Shuang Dai & Xiaomin Fang
doi:10.1038/nature05516
First paragraph | Full Text | PDF (434K) | Supplementary information
See also: Editor's summary | News and Views by Bowen
Large temperature drop across the Eocene–Oligocene transition in central North America p639
Alessandro Zanazzi, Matthew J. Kohn, Bruce J. MacFadden & Dennis O. Terry
doi:10.1038/nature05551
First paragraph | Full Text | PDF (268K) | Supplementary information
See also: Editor's summary | News and Views by Bowen
Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models p643
Anatol C. Kreitzer & Robert C. Malenka
doi:10.1038/nature05506
First paragraph | Full Text | PDF (626K) | Supplementary information
See also: Editor's summary
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis p648
Yan Zheng, Dimitry M. Danilenko, Patricia Valdez, Ian Kasman, Jeffrey Eastham-Anderson, Jianfeng Wu & Wenjun Ouyang
doi:10.1038/nature05505
First paragraph | Full Text | PDF (714K) | Supplementary information
Direct control of shoot meristem activity by a cytokinin-activating enzyme p652
Takashi Kurakawa, Nanae Ueda, Masahiko Maekawa, Kaoru Kobayashi, Mikiko Kojima, Yasuo Nagato, Hitoshi Sakakibara & Junko Kyozuka
doi:10.1038/nature05504
First paragraph | Full Text | PDF (670K) | Supplementary information
See also: Editor's summary
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas p656
Wen Xue, Lars Zender, Cornelius Miething, Ross A. Dickins, Eva Hernando, Valery Krizhanovsky, Carlos Cordon-Cardo & Scott W. Lowe
doi:10.1038/nature05529
First paragraph | Full Text | PDF (991K) | Supplementary information
See also: Editor's summary | News and Views by Sharpless & DePinho
Restoration of p53 function leads to tumour regression in vivo p661
Andrea Ventura, David G. Kirsch, Margaret E. McLaughlin, David A. Tuveson, Jan Grimm, Laura Lintault, Jamie Newman, Elizabeth E. Reczek, Ralph Weissleder & Tyler Jacks
doi:10.1038/nature05541
First paragraph | Full Text | PDF (776K) | Supplementary information
See also: Editor's summary | News and Views by Sharpless & DePinho
Repression of the human dihydrofolate reductase gene by a non-coding interfering transcript p666
Igor Martianov, Aroul Ramadass, Ana Serra Barros, Natalie Chow & Alexandre Akoulitchev
doi:10.1038/nature05519
First paragraph | Full Text | PDF (387K) | Supplementary information
See also: Editor's summary
Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation p671
Guillermo Barreto, Andrea Schäfer, Joachim Marhold, Dirk Stach, Suresh K. Swaminathan, Vikas Handa, Gabi Döderlein, Nicole Maltry, Wei Wu, Frank Lyko & Christof Niehrs
doi:10.1038/nature05515
First paragraph | Full Text | PDF (488K) | Supplementary information
See also: Editor's summary
Naturejobs
ProspectDrug industry mergers means career reconsiderations for scientists. p677
Paul Smaglik
doi:10.1038/nj7128-677a
Special Report
Taxi-Cab Teaching p678
Short-term appointments are on the rise for teachers at colleges and universities around the world. Are these 'contingent' staff being taken for a ride? Heidi Ledford reports.
Heidi Ledford
doi:10.1038/nj7128-678a
Career Views
Daniel Zajfman, president, Weizmann Institute of Science, Rehovot, Israel p680
Israeli physicist takes the helm at the Weizmann Institute
Nora Eichinger
doi:10.1038/nj7128-680a
Seeking a PhD abroad p680
English student heads to Germany to expand horizons.
Michael Banks
doi:10.1038/nj7128-680b
Making a difference p680
Australian postdoc ponders switching fields.
Peter Jordan
doi:10.1038/nj7128-680c
Recruitment
Time for a change p682
Universities, businesses, students and employees all need to rethink they way they approach training.
Michael Alvarez
doi:10.1038/nj7128-682a