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News and Views
Nature 445, 606-607 (8 February 2007) | doi:10.1038/nature05567; Published online 24 January 2007
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Cancer biology: Gone but not forgotten
Norman E. Sharpless1 & Ronald A. DePinho2
Abstract
The p53 tumour-suppressor protein is a cell's principal guardian against cancer. Most cancers eliminate p53 — but it seems that its pathway remains intact, so resurrecting it might provide a cancer therapy.
Once fully established, many cancers rely for their maintenance on the persistent activation of certain cancer-promoting genes (oncogenes)1, 2. Drug developers hope to exploit this dependency, as it makes tumours vulnerable to inhibitors of the associated oncogenic proteins.
- Norman E. Sharpless is in the Department of Medicine and Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Email: nes@med.unc.edu - Ronald A. DePinho is in the Center for Applied Cancer Science and Departments of Medical Oncology, Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Email: ron_depinho@dfci.harvard.edu
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