FIGURE 2. p53 restoration leads to tumour regression in vivo.

From the following article:

Restoration of p53 function leads to tumour regression in vivo

Andrea Ventura, David G. Kirsch, Margaret E. McLaughlin, David A. Tuveson, Jan Grimm, Laura Lintault, Jamie Newman, Elizabeth E. Reczek, Ralph Weissleder & Tyler Jacks

Nature 445, 661-665(8 February 2007)



a, Flow chart of the strategy used to determine tumour response. i.p., intraperitoneal. bd, MRI images (top) and tumour volumes (bottom) of p53-LSL;Cre-ERT2 (b, c) and p53-LSL (d, e) mice in response to tamoxifen (arrows). The tumours (asterisks) were an abdominal lymphoma (b), two thymic lymphomas (t. lymphoma; c and d, white asterisks) and two sarcomas (c and e, red asterisks). The volumes were calculated from the available MRI sequences (n  =  2 to 6) for each time point, and are shown as mean + 1 s.d. f, Summary of maximal responses to tamoxifen of tumours from Cre-ERT2-positive (grey bars) and Cre-ERT2-negative (blue bars) mice. Asterisks indicate tumours from Cre-ERT2-positive mice with limited or no response (see also Supplementary Fig. S3).