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Nature 445, 559-562 (21 January 2007) | doi:10.1038/nature05469;
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TPP1 is a homologue of ciliate TEBP-|[bgr]| and interacts with POT1 to recruit telomerase
Telomere dysfunction may result in chromosomal abnormalities, DNA damage responses, and even cancer. Early studies in lower organisms have helped to establish the crucial role of telomerase and telomeric proteins in maintaining telomere length and protecting telomere ends.
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