Table of contents
Volume 445 Number 7127 pp459-566
Editorials
Brave blue world p459
Human spaceflight is no excuse for ignoring the home planet, which needs constant monitoring from space.
doi:10.1038/445459a
See also: Editor's summary
Defence deficit p459
A public debate about renewing Britain's nuclear weaponry is undermined by excessive secrecy.
doi:10.1038/445459b
A changing drug supply p460
Research cuts by the world's largest drug company reflect a challenging outlook for the industry.
doi:10.1038/445460a
News
Blair under fire over Trident 'secrecy' p464
Government rebuffs expert advice on submarine fleet.
Jim Giles
doi:10.1038/445464a
California institute woos NIH stem-cell chief p464
James Battey is in the frame for president's job.
Meredith Wadman
doi:10.1038/445464b
Bush splashes out on ocean research p465
President offers marine science $140-million cash boost.
Emma Marris
doi:10.1038/445465a
Infertility researchers target uterus transplant p466
Surgeons optimistic operations could succeed.
Helen Pearson
doi:10.1038/445466a
Michigan lab axed as Pfizer cuts costs p466
Staff in shock as drug giant restructures research.
Meredith Wadman
doi:10.1038/445466b
Sidelines p468
doi:10.1038/445468a
Physicists plan search for the known unknowns p468
Experiments aim to force gravity into the equation.
Jenny Hogan
doi:10.1038/445468b
Volcano gets choke chains to slow mud p470
Geophysicists offer concrete proposal to stem East Java eruption.
David Cyranoski
doi:10.1038/445470a
News in brief p471
doi:10.1038/445471a
Correction p471
doi:10.1038/445471b
Business
Display of flexibility p473
Physicists at the University of Cambridge are leading a revolution in how data can best be displayed. Katharine Sanderson reports.
Katharine Sanderson
doi:10.1038/445473a
News Features
Space exploration: Where 24 men have gone before p474
Three years ago, President George W. Bush told NASA to return American astronauts to the Moon. Geoff Brumfiel reports on how far they have got.
doi:10.1038/445474a
See also: Editor's summary
Reproductive medicine: The first cut p479
Extracting a cell from a budding human embryo can expose genetic defects, but does it actually help generate more healthy babies? Bruce Goldman investigates.
doi:10.1038/445479a
Conservation science: Ground force p481
Is parachuting into the Amazonian jungle any way to save an ecosystem? One team of biologists thinks so. Thomas Hayden joined them on a trip to Peru to find out what they do.
doi:10.1038/445481a
See also: Editor's summary
Correspondence
Research on Tasmanian bones raises a number of ethical questions p484
Jason Coombes
doi:10.1038/445484a
Increased funding vital to competitiveness initiative p484
William Jeffrey
doi:10.1038/445484b
Five-point plan to revive and reform Indian science p484
U. C. Lavania
doi:10.1038/445484c
All sizes of needle in that overcrowded haystack p484
Neville W. Goodman
doi:10.1038/445484d
Books and Arts
For better or for worse p485
Science must be applied carefully if we are to reap the benefits but minimize the risks.
Ian Wilmut reviews Times of Triumph, Times of Doubt: Science and the Battle for Public Trust by Elof Axel Carlson
doi:10.1038/445485a
See also: Editor's summary
Painting the whole picture? p486
Philip Ball reviews Visions of Nature: The Art and Science of Ernst Haeckel by Olaf Breidbach
doi:10.1038/445486a
Drifting into art p487
doi:10.1038/445487a
Essay
ConnectionsA twenty-first century science p489
If handled appropriately, data about Internet-based communication and interactivity could revolutionize our understanding of collective human behaviour.
Duncan J. Watts
doi:10.1038/445489a
See also: Editor's summary
News and Views
Chemical biology: Sticky spices p491
The spiciness of foods such as horseradish is perceived through sensory neurons of the pain pathway. The lingering pungency of some such foods results from chemical modification of the channels that trigger these neurons.
Michael J. Caterina
doi:10.1038/nature05565
See also: Editor's summary
Materials science: Synergy in a superlattice p492
Put two types of crystal together in one lattice, and the resulting material can have properties greater than the sum of those of its individual components. Until now, that's been a difficult trick to pull off on a large scale.
James R. Heath
doi:10.1038/445492a
50 & 100 Years Ago p493
doi:10.1038/445493a
Hydrology: Tropical rain recycling p495
The behaviour of water in the atmosphere is a poorly understood part of the hydrological cycle. Applying the principles of isotope chemistry to satellite data provides a powerful approach for improving the situation.
Thom Rahn
doi:10.1038/445495a
Organic chemistry: Catalytic gold rush p496
Despite gold's reputation as an inert element, chemists have mined a rich seam of catalytic reactions that use this metal. The latest example stakes out gold's claim as a versatile catalyst.
Steven P. Nolan
doi:10.1038/445496a
Developmental biology: Moonlighting at the pole p497
Which end of a fly embryo becomes the head is partly dictated by the accumulation of bicoid RNA at the anterior pole. The protein that amasses the RNA turns out to be an old acquaintance from a different context.
Tor Erik Rusten and Harald Stenmark
doi:10.1038/445497a
See also: Editor's summary
Reproductive biology: Sperm alliance p499
Tim Lincoln
doi:10.1038/445499a
Quantum physics: Photon lab in a circuit p500
Electrical circuits might be regarded as rather mundane pieces of classical engineering. But their electromagnetic fields are, like light, a quantum object whose energy comes in discrete units — photons.
Frank K. Wilhelm and Enrique Solano
doi:10.1038/445500a
See also: Editor's summary
Brief Communications Arising
Biological scaling: Does the exception prove the rule? pE9
Brian J. Enquist, Andrew P. Allen, James H. Brown, James F. Gillooly, Andrew J. Kerkhoff, Karl J. Niklas, Charles A. Price and Geoffrey B. West
doi:10.1038/nature05548
First paragraph | Full Text | PDF (283K)
Biological scaling: Does the exception prove the rule? (Reply) pE10
Peter B. Reich, Mark G. Tjoelker, Jose-Luis Machado and Jacek Oleksyn
doi:10.1038/nature05549
First paragraph | Full Text | PDF (166K)
Biological scaling: Does the exception prove the rule? (Reply) pE11
Lars O. Hedin
doi:10.1038/nature05550
First paragraph | Full Text | PDF (79K)
Articles
Termination of asymmetric cell division and differentiation of stomata p501
Lynn Jo Pillitteri, Daniel B. Sloan, Naomi L. Bogenschutz and Keiko U. Torii
doi:10.1038/nature05467
Abstract | Full Text | PDF (1,633K) | Supplementary information
See also: Editor's summary
The POT1–TPP1 telomere complex is a telomerase processivity factor p506
Feng Wang, Elaine R. Podell, Arthur J. Zaug, Yuting Yang, Paul Baciu, Thomas R. Cech and Ming Lei
doi:10.1038/nature05454
Abstract | Full Text | PDF (1,024K) | Supplementary information
See also: Editor's summary
Letters
The signature of hot hydrogen in the atmosphere of the extrasolar planet HD 209458b p511
Gilda E. Ballester, David K. Sing and Floyd Herbert
doi:10.1038/nature05525
First paragraph | Full Text | PDF (289K) | Supplementary information
See also: Editor's summary
Resolving photon number states in a superconducting circuit p515
D. I. Schuster, A. A. Houck, J. A. Schreier, A. Wallraff, J. M. Gambetta, A. Blais, L. Frunzio, J. Majer, B. Johnson, M. H. Devoret, S. M. Girvin and R. J. Schoelkopf
doi:10.1038/nature05461
First paragraph | Full Text | PDF (643K)
See also: Editor's summary | News and Views by Wilhelm & Solano
Label-free immunodetection with CMOS-compatible semiconducting nanowires p519
Eric Stern, James F. Klemic, David A. Routenberg, Pauline N. Wyrembak, Daniel B. Turner-Evans, Andrew D. Hamilton, David A. LaVan, Tarek M. Fahmy and Mark A. Reed
doi:10.1038/nature05498
First paragraph | Full Text | PDF (1,289K) | Supplementary information
See also: Editor's summary
A molecular information ratchet p523
Viviana Serreli, Chin-Fa Lee, Euan R. Kay and David A. Leigh
doi:10.1038/nature05452
First paragraph | Full Text | PDF (642K) | Supplementary information
See also: Editor's summary
Importance of rain evaporation and continental convection in the tropical water cycle p528
John Worden, David Noone and Kevin Bowman and The Tropospheric Emission Spectrometer science team and data contributors
doi:10.1038/nature05508
First paragraph | Full Text | PDF (2,710K) | Supplementary information
See also: News and Views by Rahn
Evolution of species interactions in a biofilm community p533
Susse Kirkelund Hansen, Paul B. Rainey, Janus A. J. Haagensen and Søren Molin
doi:10.1038/nature05514
First paragraph | Full Text | PDF (616K) | Supplementary information
See also: Editor's summary
Transcription factor control of asymmetric cell divisions that establish the stomatal lineage p537
Cora A. MacAlister, Kyoko Ohashi-Ito and Dominique C. Bergmann
doi:10.1038/nature05491
First paragraph | Full Text | PDF (994K) | Supplementary information
See also: Editor's summary
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines p541
Lindsey J. Macpherson, Adrienne E. Dubin, Michael J. Evans, Felix Marr, Peter G. Schultz, Benjamin F. Cravatt and Ardem Patapoutian
doi:10.1038/nature05544
First paragraph | Full Text | PDF (1,011K) | Supplementary information
See also: Editor's summary | News and Views by Caterina
The twisted ion-permeation pathway of a resting voltage-sensing domain p546
Francesco Tombola, Medha M. Pathak, Pau Gorostiza and Ehud Y. Isacoff
doi:10.1038/nature05396
First paragraph | Full Text | PDF (5,027K) | Supplementary information
Structure prediction for the down state of a potassium channel voltage sensor p550
Michael Grabe, Helen C. Lai, Monika Jain, Yuh Nung Jan and Lily Yeh Jan
doi:10.1038/nature05494
First paragraph | Full Text | PDF (562K) | Supplementary information
bicoid RNA localization requires specific binding of an endosomal sorting complex p554
Uwe Irion and Daniel St Johnston
doi:10.1038/nature05503
First paragraph | Full Text | PDF (1,122K) | Supplementary information
See also: Editor's summary | News and Views by Rusten & Stenmark
TPP1 is a homologue of ciliate TEBP-
and interacts with POT1 to recruit telomerase p559
Huawei Xin, Dan Liu, Ma Wan, Amin Safari, Hyeung Kim, Wen Sun, Matthew S. O'Connor and Zhou Songyang
doi:10.1038/nature05469
First paragraph | Full Text | PDF (841K) | Supplementary information
See also: Editor's summary
Naturejobs
ProspectPostdocs face crossroads. p563
Paul Smaglik
doi:10.1038/nj7127-563a
Career Views
Christoph Borchers, director, University of Victoria–Genome BC Proteomics Centre, Victoria, British Columbia, Canada p564
Christoph Borchers takes over at Canadian proteomics centre.
Virginia Gewin
doi:10.1038/nj7127-564a
Better offices, better postdocs p564
Sloan Foundation funds new postdoc offices.
Virginia Gewin
doi:10.1038/nj7127-564b
Happily ever after? p564
Choosing a mentor can be excruciating.
Maria Ocampo-Hafalla
doi:10.1038/nj7127-564c
Recruitment
Bias cut p566
Women, it seems, often get a raw deal in science — so how can discrimination be tackled?
Lutz Bornmann
doi:10.1038/nj7127-566a
Highlights
Opportunities: The National Institutes of Health
doi:10.1038/nj0144