Which end of a fly embryo becomes the head is partly dictated by the accumulation of bicoid RNA at the anterior pole. The protein that amasses the RNA turns out to be an old acquaintance from a different context.
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Rusten, T., Stenmark, H. Moonlighting at the pole. Nature 445, 497–499 (2007). https://doi.org/10.1038/445497a
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DOI: https://doi.org/10.1038/445497a
