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Nature 445, 497-499 (1 February 2007) | doi:10.1038/445497a; Published online 31 January 2007

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Developmental biology: Moonlighting at the pole

Tor Erik Rusten1 & Harald Stenmark1

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Which end of a fly embryo becomes the head is partly dictated by the accumulation of bicoid RNA at the anterior pole. The protein that amasses the RNA turns out to be an old acquaintance from a different context.

Protein production can be restricted to particular areas within cells by targeting the messenger RNAs encoding them to those sites. Such localization of mRNAs can affect the function of single cells, particularly those that have a polarity such as neurons.

  1. Tor Erik Rusten and Harald Stenmark are at the Centre for Cancer Biomedicine, Norwegian Radium Hospital and the University of Oslo, Montebello, N-0310 Oslo, Norway.
    Email: stenmark@ulrik.uio.no

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