Frank J. Poelwijk, Daniel J. Kiviet, Daniel M. Weinreich & Sander J. Tans
doi:10.1038/nature05451
日本語要約 | Full Text | PDF (410K)
Table of contents
Volume 445 Number 7126 pp383-369
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Progress
進化：実験的な適応度地形は到達可能な進化的経路を明らかにする
Empirical fitness landscapes reveal accessible evolutionary paths p383
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Articles
生化学：ナトリウム依存性アスパラギン酸トランスポーターの基質およびイオンの結合と細胞外ゲートの共役
Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter p387
Olga Boudker, Renae M. Ryan, Dinesh Yernool, Keiko Shimamoto & Eric Gouaux
doi:10.1038/nature05455
生化学：ユビキチン様タンパク質のチオエステル「スイッチ」によるE1-E2親和性切り替えの基盤
Basis for a ubiquitin-like protein thioester switch toggling E1–E2 affinity p394
Danny T. Huang, Harold W. Hunt, Min Zhuang, Melanie D. Ohi, James M. Holton & Brenda A. Schulman
doi:10.1038/nature05490
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Letters
宇宙：土星の上層大気における予想外の冷却効果
An unexpected cooling effect in Saturn's upper atmosphere p399
C. G. A. Smith, A. D. Aylward, G. H. Millward, S. Miller & L. E. Moore
doi:10.1038/nature05518
原子物理学：ボソンとフェルミオンのハンブリーブラウン・トゥイス効果の比較
Comparison of the Hanbury Brown–Twiss effect for bosons and fermions p402
T. Jeltes, J. M. McNamara, W. Hogervorst, W. Vassen, V. Krachmalnicoff, M. Schellekens, A. Perrin, H. Chang, D. Boiron, A. Aspect & C. I. Westbrook
doi:10.1038/nature05513
数理物理学：勾配がないときの探索戦略となる「情報走性」
'Infotaxis' as a strategy for searching without gradients p406
Massimo Vergassola, Emmanuel Villermaux & Boris I. Shraiman
doi:10.1038/nature05464
物理：カーボンナノチューブを使ったスピン情報の強い電気シグナルへの変換
Transformation of spin information into large electrical signals using carbon nanotubes p410
Luis E. Hueso, José M. Pruneda, Valeria Ferrari, Gavin Burnell, José P. Valdés-Herrera, Benjamin D. Simons, Peter B. Littlewood, Emilio Artacho, Albert Fert & Neil D. Mathur
doi:10.1038/nature05507
工学：1011ビット/cm2にパターニングされた160キロビット分子電子メモリー
A 160-kilobit molecular electronic memory patterned at 1011 bits per square centimetre p414
Jonathan E. Green, Jang Wook Choi, Akram Boukai, Yuri Bunimovich, Ezekiel Johnston-Halperin, Erica DeIonno, Yi Luo, Bonnie A. Sheriff, Ke Xu, Young Shik Shin, Hsian-Rong Tseng, J. Fraser Stoddart & James R. Heath
doi:10.1038/nature05462
地球：海洋地殻における地震波2A層と溶岩層の厚さとの相関関係における矛盾
Inconsistent correlation of seismic layer 2a and lava layer thickness in oceanic crust p418
Gail L. Christeson, Kirk D. McIntosh & Jeffrey A. Karson
doi:10.1038/nature05517
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進化：オーストラリア中南部で見つかった更新世中期の乾燥に適応した脊椎動物相
An arid-adapted middle Pleistocene vertebrate fauna from south-central Australia p422
Gavin J. Prideaux, John A. Long, Linda K. Ayliffe, John C. Hellstrom, Brad Pillans, Walter E. Boles, Mark N. Hutchinson, Richard G. Roberts, Matthew L. Cupper, Lee J. Arnold, Paul D. Devine & Natalie M. Warburton
doi:10.1038/nature05471
進化：繊毛虫Myrionecta rubraによるクリプト植物の転写活性をもつ核の保持
Retention of transcriptionally active cryptophyte nuclei by the ciliate Myrionecta rubra p426
Matthew D. Johnson, David Oldach, Charles F. Delwiche & Diane K. Stoecker
doi:10.1038/nature05496
生態：魚は観察のみから社会的順位を推測できる
Fish can infer social rank by observation alone p429
Logan Grosenick, Tricia S. Clement & Russell D. Fernald
doi:10.1038/nature05511
細胞：二重阻害タンパク質CarabinによるカルシニューリンとRasのフィードバック阻害
Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin p433
Fan Pan, Luo Sun, David B. Kardian, Katharine A. Whartenby, Drew M. Pardoll & Jun O. Liu
doi:10.1038/nature05476
医学：キナーゼ不活性型HER3のHERファミリーチロシンキナーゼ阻害剤治療からの回避
Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3 p437
Natalia V. Sergina, Megan Rausch, Donghui Wang, Jimmy Blair, Byron Hann, Kevan M. Shokat & Mark M. Moasser
doi:10.1038/nature05474
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細胞：Runx2によるrRNA遺伝子の有糸分裂期の局在と系列特異的な転写制御
Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2 p442
Daniel W. Young, Mohammad Q. Hassan, Jitesh Pratap, Mario Galindo, Sayyed K. Zaidi, Suk-hee Lee, Xiaoqing Yang, Ronglin Xie, Amjad Javed, Jean M. Underwood, Paul Furcinitti, Anthony N. Imbalzano, Sheldon Penman, Jeffrey A. Nickerson, Martin A. Montecino, Jane B. Lian, Janet L. Stein, Andre J. van Wijnen & Gary S. Stein
doi:10.1038/nature05473
生化学：APOBEC-2の結晶構造とその脱アミノ酵素AIDの機能への影響
The APOBEC-2 crystal structure and functional implications for the deaminase AID p447
Courtney Prochnow, Ronda Bransteitter, Michael G. Klein, Myron F. Goodman & Xiaojiang S. Chen
doi:10.1038/nature05492
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News and Views
数理物理学：正しい手がかりを追う
Mathematical physics: On the right scent p371
Searching for the source of a smell is hampered by the absence of pervasive local cues that point the searcher in the right direction. A strategy based on maximal information could show the way.
Dominique Martinez
doi:10.1038/445371a
日本語要約 | Full Text | PDF (269K)
原子物理学：原子の社会生活
Atomic physics: The social life of atoms p372
In a trail-blazing experiment 50 years ago, it was observed that photons from far-off stars bunch up. But in fact there's a more general distinction among free, non-interacting particles: bosons bunch, and fermions 'antibunch'.
Maciej Lewenstein
doi:10.1038/445372a
日本語要約 | Full Text | PDF (544K)
表面化学：水をはじく脚
Surface chemistry: Repellent legs p373
構造生物学：タンパク質の受け渡し
Structural biology: Pass the protein p375
Modifier proteins, such as ubiquitin, are passed sequentially between trios of enzymes, like batons in a relay race. Crystal structures suggest the mechanism of transfer between the first two enzymes.
Jean-François Trempe & Jane A. Endicott
doi:10.1038/nature05564
日本語要約 | Full Text | PDF (284K)
50 & 100 Years Ago p376
doi:10.1038/445376a
惑星科学：エンケラドゥスの内部
Planetary science: Inside Enceladus p376
Chemical analysis of a plume emanating from near the south pole of Enceladus indicates that the interior of this saturnian moon is hot. Could it have been hot enough for complex organic molecules to be made?
John Spencer & David Grinspoon
doi:10.1038/445376b
日本語要約 | Full Text | PDF (293K)
生物地理学：ナラーバー平原の下からの収穫
Biogeography: Bounty beneath the Nullarbor p377
細胞生物学：染色体のテリトリー
Cell biology: Chromosome territories p379
The natural habitat of eukaryotic genomes is the cell nucleus, where each chromosome is confined to a discrete region, referred to as a chromosome territory. This spatial organization is emerging as a crucial aspect of gene regulation and genome stability in health and disease.
Karen J. Meaburn & Tom Misteli
doi:10.1038/445379a
日本語要約 | Full Text | PDF (785K)
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News
Special reportSaving time p344
Politicians in the United Kingdom and United States have launched efforts to extend daylight-saving measures — hoping to save lives, cut power use and combat carbon emissions. But energy experts say that it's not that easy. Michael Hopkin reports.
Michael Hopkin
doi:10.1038/445344a
How to drive light round the wrong bend p346
Negative refraction achieved at visible wavelengths.
Katharine Sanderson
doi:10.1038/445346a
PR's 'pit bull' takes on open access p347
Journal publishers lock horns with free-information movement.
Jim Giles
doi:10.1038/445347a
Interrogation comes under fire p349
Tough questioning tactics lack scientific foundation, intelligence agencies told.
Geoff Brumfiel
doi:10.1038/445349a
Sidelines p349
doi:10.1038/445349b
India's carbon dioxide trap p350
Volcanic hills could sequester greenhouse gas.
K. S. Jayaraman
doi:10.1038/445350a
Rebels hold their own in journal price war p351
Making the paper: Logan Grosenick pxiii
Abstractions pxiii
doi:10.1038/7126xiiib
Key Collaborators pxiii
doi:10.1038/7126xiiic
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Editorials
Grounds for optimism p339
A summit of Africa's leaders marks a deepening commitment to science and technology in the continent.
doi:10.1038/445339a
Clock-watching p339
Making connections p340
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Business
Crunch time for multiple-gene tests p354
Sophisticated new genetic tests face an uncertain future — unless they can win clear-cut approval from regulators, insurers and, most importantly, doctors. Virginia Gewin reports.
doi:10.1038/445354a
In brief p355
Market watch p355
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News Features
Science in Africa: All eyes on Addis p356
Next week, African leaders will come together to talk about science and technology at a summit in Ethiopia. This presents an opportunity to allot some foreign aid and, if they get it right, to launch projects that will draw further donations from abroad, says Michael Cherry.
Michael Cherry
doi:10.1038/445356a
Neuroscience: It's all in the timing p359
Taking hormones to replace those lost during menopause helps many women with their symptoms, yet it may also cause cognitive decline. Could the age at which hormones are taken determine whether they will be beneficial or harmful? Tom Siegfried reports.
Tom Siegfried
doi:10.1038/445359a
High-density memory: A switch in time p362
By 2020 the semiconductor industry wants a memory device that can store a trillion bits of information in an area the size of a postage stamp. As companies race towards this goal, chemists are coming up with an unusual approach. Philip Ball reports.
Philip Ball
doi:10.1038/445362a
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Correspondence
Journals should set a new standard in transparency p364
Robert P. Dellavalle, Kristy Lundahl, Scott R. Freeman & Lisa M. Schilling
doi:10.1038/445364a
Wise words from women aren't among top sellers p364
Polluting effects of Brazil's sugar-ethanol industry p364
Magenta and yellow in images is not a bright idea p364
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Books and Arts
Dark days at the White House p365
Has the George W. Bush administration manipulated science for political ends?
doi:10.1038/445365a
The Universe's quantum monkeys p366
doi:10.1038/445366a
Cover story p367
doi:10.1038/445367a
Science in culture p368
Chart toppers
An exhibition explores the diverse ways of putting data on the map.
Martin Kemp
doi:10.1038/445368a
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Essay
ConnectionsBiology's next revolution p369
The emerging picture of microbes as gene-swapping collectives demands a revision of such concepts as organism, species and evolution itself.
Nigel Goldenfeld & Carl Woese
doi:10.1038/445369a
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Special Report
Recruitment
Naturejobs
ProspectA better deal for postdocs and their mentors? p453
Paul Smaglik
doi:10.1038/nj7126-453a
Special Report
Lost in translation p454
English is the language of science. So to what extent are researchers who are non-native English speakers at a disadvantage? Bonnie Lee La Madeleine talks to scientists hailing from Japan to Germany.
Bonnie Lee La Madeleine
doi:10.1038/nj7126-454a
Recruitment
A degree of professionalism p458
There's a growing career path for students who like science, but don't want to be academics.
Michael S. Teitelbaum & Virginia T. Cox
doi:10.1038/nj7126-458a
