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Nature 445, 379-381 (25 January 2007) | doi:10.1038/445379a; Published online 24 January 2007

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Cell biology: Chromosome territories

Karen J. Meaburn1 & Tom Misteli1

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The natural habitat of eukaryotic genomes is the cell nucleus, where each chromosome is confined to a discrete region, referred to as a chromosome territory. This spatial organization is emerging as a crucial aspect of gene regulation and genome stability in health and disease.

What do chromosome territories look like?The word 'chromosome' usually conjures up striking images of the dense, X-shaped entities seen during cell division.

  1. Karen J. Meaburn and Tom Misteli are at the National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.

Correspondence to: Tom Misteli1 Email: mistelit@mail.nih.gov

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