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Nature 445, 272-274 (18 January 2007) | doi:10.1038/445272a; Published online 17 January 2007
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Faculty - Plant Cellular & Molecular Biology, Molecular Genetics & the Plant Molecular Biology / Biotechnology Program
- The Ohio State University
- Columbus, Ohio
Endowed Professorship
- Washington University School of Medicine in St. Louis
- St. Louis, MO 63110 United States
Cell biology: A switch for S phase
Michael Botchan1
Abstract
DNA replication is a necessary prelude to the division of a eukaryotic cell. Initiation of this process requires a complex script, involving many proteins: details of one of the main acts now emerge.
In 1992, a report by Li and Alberts1 appeared in these pages to comment on a seminal discovery2 — the identification of the protein factors from the budding yeast Saccharomyces cerevisiae that recognize the spots on DNA for initiating the DNA-replication phase of the cell cycle. Finding this 'origin-recognition complex' was one task, however; identifying the participants in the actual switch that starts DNA synthesis is another.
- Michael Botchan is in the Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California 94720-3200, USA.
Email: mbotchan@berkeley.edu
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