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News and Views
Nature 445, 267-268 (18 January 2007) | doi:10.1038/445267a; Published online 17 January 2007
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Influenza: Fatal immunity and the 1918 virus
Yueh-Ming Loo1 & Michael Gale, Jr1
Abstract
Innate immune defences are our first line of protection against infection by viruses and are essential in limiting viral disease. But their reaction to the 1918 influenza virus could have been deadly.
The devastating Spanish influenza A virus infected around a third of the world's population during the pandemic of 1918. With mortality rates more than 25 times that of other influenza pandemics, the 1918 virus killed over 40 million people worldwide1.
- Yueh-Ming Loo and Michael Gale Jr are in the Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9048, USA.
Email: michael.gale@utsouthwestern.edu
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