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Commentary

Nature 445, 259 (18 January 2007) | doi:10.1038/445259a; Published online 17 January 2007

Open Innovation Challenges

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Merging and emerging cohorts: Necessary but not sufficient

Francis S. Collins1 & Teri A. Manolio1

  1. Francis S. Collins and Teri A. Manolio are at the National Human Genome Research Institute, National Institutes of Health, 31 Center Drive, Bethesda, Maryland 20892-2152, USA.

The proposal advocated in the preceding Commentary by Willett et al.1, namely to extend existing cohort studies rather than start a new large-scale prospective study from scratch, has many merits. Indeed, a US National Institutes of Health (NIH) study group that assessed the pros and cons of various models in 2004 considered this option in some depth, and their report2 made many of the same points.

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