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Brief Communications Arising
Nature 445, E2-E3 (4 January 2007) | doi:10.1038/nature05534; Published online 3 January 2007
Neurophysiology: Hodgkin and Huxley model — still standing? (Reply)
Björn Naundorf1, Fred Wolf1 & Maxim Volgushev2
Abstract
McCormick et al.1 question whether the rapid onset and highly variable thresholds of action potentials2 are genuine features of cortical action-potential generators — that is, whether they reflect the voltage-dependence of the underlying sodium currents. Instead, they consider these features to be epiphenomena, reflecting lateral currents from a remote initiation site, and, contrary to direct evidence3, they assume that sodium currents show canonical kinetics.
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RESEARCH
Unique features of action potential initiation in cortical neuronsNature Letters to Editor (20 Apr 2006)
Neurophysiology Hodgkin and Huxley model ? still standing?Nature Brief Communication (04 Jan 2007)