Abstract
McCormick et al.1 question whether the rapid onset and highly variable thresholds of action potentials2 are genuine features of cortical action-potential generators — that is, whether they reflect the voltage-dependence of the underlying sodium currents. Instead, they consider these features to be epiphenomena, reflecting lateral currents from a remote initiation site, and, contrary to direct evidence3, they assume that sodium currents show canonical kinetics.
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References
McCormick, D. A., Shu, Y. & Yu, Y. Nature 445, 10.1038/nature05523 (2007).
Naundorf, B., Wolf, F. & Volgushev, M. Nature 440, 1060–1063 (2006).
Baranauskas, G. & Martina, M. J. Neurosci. 26, 671–684 (2006).
Spira, M. E., Oren, R., Dormann, A., Ilouz, N. & Lev, S. Cell Mol. Neurobiol. 21, 591–604 (2002).
Lacas-Gervais, S. et al. J. Cell Biol. 166, 983–990 (2004).
Rush, A. M., Dib-Hajj, S. D. & Waxman, S. G. J. Physiol. 564, 803–815 (2005).
Colbert, C. M. & Pan, E. Nature Neurosci. 5, 533–538 (2002).
Ruben, P. C., Ilscher, S. U., Williams, S. R. & Stuart, G. J. Soc. Neurosci. abstr. 476.2 (2003).
Waters, J., Schaefer, A. & Sakmann, B. Progr. Biophys. Mol. Biol. 87, 145–170 (2005).
Fourcaud-Trocme, N., Hansel, D., van Vreeswijk, C. & Brunel, N. J. Neurosci. 23, 11628–11640 (2003).
Naundorf, B., Geisel, T. & Wolf, F. J. Comput. Neurosci. 18, 297–309 (2005).
Silberberg, G., Bethge, M., Markram, H., Pawelzik, K. & Tsodyks, M. J. Neurophysiol. 91, 704–709 (2004).
Williams, P. E., Mechler, F., Gordon, J., Shapley, R. & Hawken, M. J. J. Neurosci. 24, 8278–8288 (2004).
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Naundorf, B., Wolf, F. & Volgushev, M. Hodgkin and Huxley model — still standing? (Reply). Nature 445, E2–E3 (2007). https://doi.org/10.1038/nature05534
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DOI: https://doi.org/10.1038/nature05534
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