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Nature 444, 1083-1087 (21 December 2006) | doi:10.1038/nature05313;
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Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
Haploinsufficiency of Dll4, a vascular-specific Notch ligand, has shown that it is essential for embryonic vascular development and arteriogenesis. Mechanistically, it is unclear how the Dll4-mediated Notch pathway contributes to complex vascular processes that demand meticulous coordination of multiple signalling pathways.
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