FIGURE 2. Interaction between the HCC domain of BoNT/B and the recognition domain of Syt-II.
From the following article:
Structural basis of cell surface receptor recognition by botulinum neurotoxin B
Qing Chai, Joseph W. Arndt, Min Dong, William H. Tepp, Eric A. Johnson, Edwin R. Chapman & Raymond C. Stevens
Nature 444, 1096-1100(21 December 2006)
doi:10.1038/nature05411
a, Binding interface on BoNT/B (circled in dashed line) reveals hydrophobic groove (green, hydrophobic surface). b, Close-up view of the binding interface of Syt-II (magenta) and BoNT/B (light blue) by rotating 90° around the x axis. c, Truncation mutants of Syt-II were tested for BoNT/B binding activity. d, Point mutants of Syt-II were tested for BoNT/B binding activity. e, f, Various synaptotagmin mutants, in which residues within the recognition domain were interconverted between Syt-II and Syt-I, were tested for BoNT/B binding activity. WT, wild type; GST, glutathione S-transferase.
