Figures and Tables

From the following article:

Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity

Rongsheng Jin, Andreas Rummel, Thomas Binz & Axel T. Brunger

Nature 444, 1092-1095(21 December 2006)

doi:10.1038/nature05387

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Structure of the HCB–Syt-II complex.

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Figure 2

The HCB–Syt-II complex is stabilized by extensive intermolecular interactions involving two pronounced pockets on the HCB surface.

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Figure 3

Site-directed mutagenesis analysis of the toxin-receptor binding site in BoNT/B and in the luminal domains of Syt-I and Syt-II.

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Figure 4

Simultaneous binding with membrane-anchored Syt-II and ganglioside imposes geometric restrictions on how BoNT/B binds to the membrane surface.

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