FIGURE 3. Selective blocking of Dll4 disrupts tumour angiogenesis and inhibits tumour growth.
From the following article:
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
John Ridgway, Gu Zhang, Yan Wu, Scott Stawicki, Wei-Ching Liang, Yvan Chanthery, Joe Kowalski, Ryan J. Watts, Christopher Callahan, Ian Kasman, Mallika Singh, May Chien, Christine Tan, Jo-Anne S. Hongo, Fred de Sauvage, Greg Plowman & Minhong Yan
Nature 444, 1083-1087(21 December 2006)
doi:10.1038/nature05313
a–f, Results of six tumour models: HM7 (a), Colo205 (b), Calu6 (c), MDA-MB-435 (d), MV-522 (e) and WEHI3 (f). Mean tumour volumes with standard errors are presented (n = 10). g, h, Tumour vascular histology studies. g, Immunohistochemisty of anti-CD31 in EL4 tumour sections from control, anti-Dll4 and anti-VEGF treated mice. Quantification of CD31 staining was performed using Image J. Bars represent the mean 
s.e.m. (n = 6–10, * and ** denote P values of 0.001 and 0.0001, respectively). h, Lectin perfusion and anti-CD31 staining of EL4 tumour sections.
