
Provider: Nature Publishing Group
Content: application/x-research-info-systems
TY  - GEN
TI  - Reducing Risks, Promoting Healthy Life
PY  - 2002///
ER  -

TY  - JOUR
AU  - Rocchini, A. P.
TI  - Childhood obesity and a diabetes epidemic
JA  - N. Engl. J. Med.
PY  - 2002///
VL  - 346
SP  - 854
EP  - 855
M3  - 10.1056/NEJM200203143461112
N1  - 10.1056/NEJM200203143461112
UR  - http://dx.doi.org/10.1056/NEJM200203143461112
ER  -

TY  - JOUR
AU  - Semenkovich, C. F.
TI  - Insulin resistance and atherosclerosis
JA  - J. Clin. Invest.
PY  - 2006///
VL  - 116
SP  - 1813
EP  - 1822
M3  - 10.1172/JCI29024
N1  - 10.1172/JCI29024
UR  - http://dx.doi.org/10.1172/JCI29024
ER  -

TY  - JOUR
AU  - Wellen, K. E.
AU  - Hotamisligil, G. S.
TI  - Inflammation, stress, and diabetes
JA  - J. Clin. Invest.
PY  - 2005///
VL  - 115
SP  - 1111
EP  - 1119
M3  - 10.1172/JCI200525102
N1  - 10.1172/JCI200525102
UR  - http://dx.doi.org/10.1172/JCI200525102
ER  -

TY  - JOUR
AU  - Larsen, G. L.
AU  - Henson, P. M.
TI  - Mediators of inflammation
JA  - Annu. Rev. Immunol.
PY  - 1983///
VL  - 1
SP  - 335
EP  - 359
M3  - 10.1146/annurev.iy.01.040183.002003
N1  - 10.1146/annurev.iy.01.040183.002003
UR  - http://dx.doi.org/10.1146/annurev.iy.01.040183.002003
ER  -

TY  - JOUR
AU  - Beutler, B.
TI  - Innate immunity: an overview
JA  - Mol. Immunol.
PY  - 2004///
VL  - 40
SP  - 845
EP  - 859
M3  - 10.1016/j.molimm.2003.10.005
N1  - 10.1016/j.molimm.2003.10.005
UR  - http://dx.doi.org/10.1016/j.molimm.2003.10.005
ER  -

TY  - JOUR
AU  - Levin, B. R.
AU  - Lipsitch, M.
AU  - Bonhoeffer, S.
TI  - Population biology, evolution, and infectious disease: convergence and synthesis
JA  - Science
PY  - 1999///
VL  - 283
SP  - 806
EP  - 809
M3  - 10.1126/science.283.5403.806
N1  - 10.1126/science.283.5403.806
UR  - http://dx.doi.org/10.1126/science.283.5403.806
ER  -

TY  - JOUR
AU  - Sondergaard, L.
TI  - Homology between the mammalian liver and the Drosophila fat body
JA  - Trends Genet.
PY  - 1993///
VL  - 9
SP  - 193
M3  - 10.1016/0168-9525(93)90113-V
N1  - 10.1016/0168-9525(93)90113-V
UR  - http://dx.doi.org/10.1016/0168-9525(93)90113-V
ER  -

TY  - JOUR
AU  - Leclerc, V.
AU  - Reichhart, J. M.
TI  - The immune response of Drosophila melanogaster
JA  - Immunol. Rev.
PY  - 2004///
VL  - 198
SP  - 59
EP  - 71
M3  - 10.1111/j.0105-2896.2004.0130.x
N1  - 10.1111/j.0105-2896.2004.0130.x
UR  - http://dx.doi.org/10.1111/j.0105-2896.2004.0130.x
ER  -

TY  - JOUR
AU  - Tong, Q.
TI  - Function of GATA transcription factors in preadipocyte-adipocyte transition
JA  - Science
PY  - 2000///
VL  - 290
SP  - 134
EP  - 138
M3  - 10.1126/science.290.5489.134
N1  - 10.1126/science.290.5489.134
UR  - http://dx.doi.org/10.1126/science.290.5489.134
ER  -

TY  - JOUR
AU  - Rusten, T. E.
TI  - Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway
JA  - Dev. Cell
PY  - 2004///
VL  - 7
SP  - 179
EP  - 192
M3  - 10.1016/j.devcel.2004.07.005
N1  - 10.1016/j.devcel.2004.07.005
UR  - http://dx.doi.org/10.1016/j.devcel.2004.07.005
ER  -

TY  - JOUR
AU  - Song, M. J.
AU  - Kim, K. H.
AU  - Yoon, J. M.
AU  - Kim, J. B.
TI  - Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes
JA  - Biochem. Biophys. Res. Commun.
PY  - 2006///
VL  - 346
SP  - 739
EP  - 745
M3  - 10.1016/j.bbrc.2006.05.170
N1  - 10.1016/j.bbrc.2006.05.170
UR  - http://dx.doi.org/10.1016/j.bbrc.2006.05.170
ER  -

TY  - JOUR
AU  - Shi, H.
TI  - TLR4 links innate immunity and fatty acid-induced insulin resistance
JA  - J. Clin. Invest.
PY  - 2006///
VL  - 116
SP  - 3015
EP  - 3025
M3  - 10.1172/JCI28898
N1  - 10.1172/JCI28898
UR  - http://dx.doi.org/10.1172/JCI28898
ER  -

TY  - JOUR
AU  - Shoelson, S. E.
AU  - Lee, J.
AU  - Goldfine, A. B.
TI  - Inflammation and insulin resistance
JA  - J. Clin. Invest.
PY  - 2006///
VL  - 116
SP  - 1793
EP  - 1801
M3  - 10.1172/JCI29069
N1  - 10.1172/JCI29069
UR  - http://dx.doi.org/10.1172/JCI29069
ER  -

TY  - JOUR
AU  - Dionne, M.
AU  - Pham, L. N.
AU  - Shirasu-Hiza, M.
AU  - Schneider, D. S.
TI  - Akt and foxo dysregulation contribute to infection-induced wasting in Drosophila
JA  - Curr. Biol.
PY  - 2006///
VL  - 16
SP  - 1977
EP  - 1985
M3  - 10.1016/j.cub.2006.08.052
N1  - 10.1016/j.cub.2006.08.052
UR  - http://dx.doi.org/10.1016/j.cub.2006.08.052
ER  -

TY  - JOUR
AU  - Charlton, M. R.
AU  - Pockros, P. J.
AU  - Harrison, S. A.
TI  - Impact of obesity on treatment of chronic hepatitis C
JA  - Hepatology
PY  - 2006///
VL  - 43
SP  - 1177
EP  - 1186
M3  - 10.1002/hep.21239
N1  - 10.1002/hep.21239
UR  - http://dx.doi.org/10.1002/hep.21239
ER  -

TY  - JOUR
AU  - Dandona, P.
AU  - Aljada, A.
AU  - Bandyopadhyay, A.
TI  - Inflammation: the link between insulin resistance, obesity and diabetes
JA  - Trends Immunol.
PY  - 2004///
VL  - 25
SP  - 4
EP  - 7
M3  - 10.1016/j.it.2003.10.013
N1  - 10.1016/j.it.2003.10.013
UR  - http://dx.doi.org/10.1016/j.it.2003.10.013
ER  -

TY  - JOUR
AU  - Hotamisligil, G. S.
AU  - Shargill, N. S.
AU  - Spiegelman, B. M.
TI  - Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
JA  - Science
PY  - 1993///
VL  - 259
SP  - 87
EP  - 91
M3  - 10.1126/science.7678183
N1  - 10.1126/science.7678183
UR  - http://dx.doi.org/10.1126/science.7678183
ER  -

TY  - JOUR
AU  - Uysal, K..T
AU  - Wiesbrock, S. M.
AU  - Marino, M. W.
AU  - Hotamisligil, G. S.
TI  - Protection from obesity-induced insulin resistance in mice lacking TNF-[alpha] function
JA  - Nature
PY  - 1997///
VL  - 389
SP  - 610
EP  - 614
M3  - 10.1038/39335
N1  - 10.1038/39335
UR  - http://dx.doi.org/10.1038/39335
ER  -

TY  - JOUR
AU  - Ventre, J.
TI  - Targeted disruption of the tumor necrosis factor-alpha gene [mdash] metabolic consequences in obese and nonobese mice
JA  - Diabetes
PY  - 1997///
VL  - 46
SP  - 1526
EP  - 1531
ER  -

TY  - JOUR
AU  - Hotamisligil, G. S.
AU  - Arner, P.
AU  - Caro, J. F.
AU  - Atkinson, R. L.
AU  - Spiegelman, B. M.
TI  - Increased adipose tissue expression of tumor necrosis factor-[alpha] in human obesity and insulin resistance
JA  - J. Clin. Invest.
PY  - 1995///
VL  - 95
SP  - 2409
EP  - 2415
ER  -

TY  - JOUR
AU  - Kern, P. A.
TI  - The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase
JA  - J. Clin. Invest.
PY  - 1995///
VL  - 95
SP  - 2111
EP  - 2119
ER  -

TY  - JOUR
AU  - Saghizadeh, M.
AU  - Ong, J. M.
AU  - Garvey, W. T.
AU  - Henry, R. R.
AU  - Kern, P. A.
TI  - The expression of TNF[alpha] by human muscle: relationship to insulin resistance
JA  - J. Clin. Invest.
PY  - 1996///
VL  - 97
SP  - 1111
EP  - 1116
ER  -

TY  - JOUR
AU  - Krogh-Madsen, R.
AU  - Plomgaard, P.
AU  - Moller, K.
AU  - Mittendorfer, B.
AU  - Pedersen, B. K.
TI  - Influence of TNF-[alpha] and IL-6 infusions on insulin sensitivity and expression of IL-18 in humans
JA  - Am. J. Physiol. Endocrinol. Metab.
PY  - 2006///
VL  - 291
SP  - E108
EP  - E114
M3  - 10.1152/ajpendo.00471.2005
N1  - 10.1152/ajpendo.00471.2005
UR  - http://dx.doi.org/10.1152/ajpendo.00471.2005
ER  -

TY  - JOUR
AU  - Ofei, F.
AU  - Hurel, S.
AU  - Newkirk, J.
AU  - Sopwith, M.
AU  - Taylor, K.
TI  - Effects of an engineered human anti-TNF-[alpha] antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM
JA  - Diabetes
PY  - 1996///
VL  - 45
SP  - 881
EP  - 885
ER  -

TY  - JOUR
AU  - Gonzalez-Gay, M. A.
TI  - Anti-tumor necrosis factor-[alpha] blockade improves insulin resistance in patients with rheumatoid arthritis
JA  - Clin. Exp. Rheumatol.
PY  - 2006///
VL  - 24
SP  - 83
EP  - 86
ER  -

TY  - JOUR
AU  - Kiortsis, D. N.
AU  - Mavridis, A. K.
AU  - Vasakos, S.
AU  - Nikas, S. N.
AU  - Drosos, A. A.
TI  - Effects of infliximab treatment on insulin resistance in patients with rheumatoid arthritis and ankylosing spondylitis
JA  - Ann. Rheum. Dis.
PY  - 2005///
VL  - 64
SP  - 765
EP  - 766
M3  - 10.1136/ard.2004.026534
N1  - 10.1136/ard.2004.026534
UR  - http://dx.doi.org/10.1136/ard.2004.026534
ER  -

TY  - JOUR
AU  - Weisberg, S. P.
TI  - Obesity is associated with macrophage accumulation in adipose tissue
JA  - J. Clin. Invest.
PY  - 2003///
VL  - 112
SP  - 1796
EP  - 1808
M3  - 10.1172/JCI200319246
N1  - 10.1172/JCI200319246
UR  - http://dx.doi.org/10.1172/JCI200319246
ER  -

TY  - JOUR
AU  - Xu, H.
TI  - Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
JA  - J. Clin. Invest.
PY  - 2003///
VL  - 112
SP  - 1821
EP  - 1830
M3  - 10.1172/JCI200319451
N1  - 10.1172/JCI200319451
UR  - http://dx.doi.org/10.1172/JCI200319451
ER  -

TY  - JOUR
AU  - Cinti, S.
TI  - Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
JA  - J. Lipid Res.
PY  - 2005///
VL  - 46
SP  - 2347
EP  - 2355
ER  -

TY  - JOUR
AU  - Arkan, M. C.
TI  - IKK-[beta] links inflammation to obesity-induced insulin resistance
JA  - Nature Med.
PY  - 2005///
VL  - 11
SP  - 191
EP  - 198
M3  - 10.1038/nm1185
N1  - 10.1038/nm1185
UR  - http://dx.doi.org/10.1038/nm1185
ER  -

TY  - JOUR
AU  - Baumgartl, J.
TI  - Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis
JA  - Cell Metab.
PY  - 2006///
VL  - 3
SP  - 247
EP  - 256
ER  -

TY  - JOUR
AU  - Han, S.
TI  - Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions
JA  - Cell Metab.
PY  - 2006///
VL  - 3
SP  - 257
EP  - 266
ER  -

TY  - JOUR
AU  - Yu, C.
TI  - Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
JA  - J. Biol. Chem.
PY  - 2002///
VL  - 277
SP  - 50230
EP  - 50236
M3  - 10.1074/jbc.M200958200
N1  - 10.1074/jbc.M200958200
UR  - http://dx.doi.org/10.1074/jbc.M200958200
ER  -

TY  - JOUR
AU  - Chawla, A.
AU  - Repa, J. J.
AU  - Evans, R. M.
AU  - Mangelsdorf, D. J.
TI  - Nuclear receptors and lipid physiology: opening the X-files
JA  - Science
PY  - 2001///
VL  - 294
SP  - 1866
EP  - 1870
M3  - 10.1126/science.294.5548.1866
N1  - 10.1126/science.294.5548.1866
UR  - http://dx.doi.org/10.1126/science.294.5548.1866
ER  -

TY  - JOUR
AU  - Glass, C. K.
AU  - Ogawa, S.
TI  - Combinatorial roles of nuclear receptors in inflammation and immunity
JA  - Nature Rev. Immunol.
PY  - 2006///
VL  - 6
SP  - 44
EP  - 55
M3  - 10.1038/nri1748
N1  - 10.1038/nri1748
UR  - http://dx.doi.org/10.1038/nri1748
ER  -

TY  - JOUR
AU  - Lee, C. H.
AU  - Olson, P.
AU  - Evans, R. M.
TI  - Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors
JA  - Endocrinology
PY  - 2003///
VL  - 144
SP  - 2201
EP  - 2207
M3  - 10.1210/en.2003-0288
N1  - 10.1210/en.2003-0288
UR  - http://dx.doi.org/10.1210/en.2003-0288
ER  -

TY  - JOUR
AU  - Joseph, S. B.
AU  - Castrillo, A.
AU  - Laffitte, B. A.
AU  - Mangelsdorf, D. J.
AU  - Tontonoz, P.
TI  - Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
JA  - Nature Med.
PY  - 2003///
VL  - 9
SP  - 213
EP  - 219
M3  - 10.1038/nm820
N1  - 10.1038/nm820
UR  - http://dx.doi.org/10.1038/nm820
ER  -

TY  - JOUR
AU  - Castrillo, A.
TI  - Crosstalk between LXR and Toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism
JA  - Mol. Cell
PY  - 2003///
VL  - 12
SP  - 805
EP  - 816
M3  - 10.1016/S1097-2765(03)00384-8
N1  - 10.1016/S1097-2765(03)00384-8
UR  - http://dx.doi.org/10.1016/S1097-2765(03)00384-8
ER  -

TY  - JOUR
AU  - Lin, Y.
TI  - The lipopolysaccharide-activated Toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes
JA  - J. Biol. Chem.
PY  - 2000///
VL  - 275
SP  - 24255
EP  - 24263
M3  - 10.1074/jbc.M002137200
N1  - 10.1074/jbc.M002137200
UR  - http://dx.doi.org/10.1074/jbc.M002137200
ER  -

TY  - JOUR
AU  - Bookout, A. L.
TI  - Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network
JA  - Cell
PY  - 2006///
VL  - 126
SP  - 789
EP  - 799
M3  - 10.1016/j.cell.2006.06.049
N1  - 10.1016/j.cell.2006.06.049
UR  - http://dx.doi.org/10.1016/j.cell.2006.06.049
ER  -

TY  - JOUR
AU  - Ogawa, S.
TI  - Molecular determinants of crosstalk between nuclear receptors and Toll-like receptors
JA  - Cell
PY  - 2005///
VL  - 122
SP  - 707
EP  - 721
M3  - 10.1016/j.cell.2005.06.029
N1  - 10.1016/j.cell.2005.06.029
UR  - http://dx.doi.org/10.1016/j.cell.2005.06.029
ER  -

TY  - JOUR
AU  - Makowski, L.
TI  - Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis
JA  - Nature Med.
PY  - 2001///
VL  - 7
SP  - 699
EP  - 705
M3  - 10.1038/89076
N1  - 10.1038/89076
UR  - http://dx.doi.org/10.1038/89076
ER  -

TY  - JOUR
AU  - Rosen, E. D.
AU  - Spiegelman, B. M.
TI  - PPAR[gamma]: a nuclear regulator of metabolism, differentiation, and cell growth
JA  - J. Biol. Chem.
PY  - 2001///
VL  - 276
SP  - 37731
EP  - 37734
M3  - 10.1074/JBC.M106424200
N1  - 10.1074/JBC.M106424200
UR  - http://dx.doi.org/10.1074/JBC.M106424200
ER  -

TY  - JOUR
AU  - Hotamisligil, G. S.
TI  - Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein
JA  - Science
PY  - 1996///
VL  - 274
SP  - 1377
EP  - 1379
M3  - 10.1126/science.274.5291.1377
N1  - 10.1126/science.274.5291.1377
UR  - http://dx.doi.org/10.1126/science.274.5291.1377
ER  -

TY  - JOUR
AU  - Maeda, K.
TI  - Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes
JA  - Cell Metab.
PY  - 2005///
VL  - 1
SP  - 107
EP  - 119
ER  -

TY  - JOUR
AU  - Tuncman, G.
TI  - A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease
JA  - Proc. Natl Acad. Sci. USA
PY  - 2006///
VL  - 103
SP  - 6970
EP  - 6975
M3  - 10.1073/pnas.0602178103
N1  - 10.1073/pnas.0602178103
UR  - http://dx.doi.org/10.1073/pnas.0602178103
ER  -

TY  - JOUR
AU  - Shum, B. O.
TI  - The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation
JA  - J. Clin. Invest.
PY  - 2006///
VL  - 116
SP  - 2183
EP  - 2192
M3  - 10.1172/JCI24767
N1  - 10.1172/JCI24767
UR  - http://dx.doi.org/10.1172/JCI24767
ER  -

TY  - JOUR
AU  - Makowski, L.
AU  - Hotamisligil, G. S.
TI  - Fatty acid binding proteins [mdash] the evolutionary crossroads of inflammatory and metabolic responses
JA  - J. Nutr.
PY  - 2004///
VL  - 134
SP  - 2464S
EP  - 2468S
ER  -

TY  - JOUR
AU  - Taniguchi, C. M.
AU  - Emanuelli, B.
AU  - Kahn, C. R.
TI  - Critical nodes in signalling pathways: insights into insulin action
JA  - Nature Rev. Mol. Cell Biol.
PY  - 2006///
VL  - 7
SP  - 85
EP  - 96
M3  - 10.1038/nrm1837
N1  - 10.1038/nrm1837
UR  - http://dx.doi.org/10.1038/nrm1837
ER  -

TY  - JOUR
AU  - White, M. F.
TI  - IRS proteins and the common path to diabetes
JA  - Am. J. Physiol. Endocrinol. Metab.
PY  - 2002///
VL  - 283
SP  - E413
EP  - E422
ER  -

TY  - JOUR
AU  - Hotamisligil, G. S.
TI  - IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-[alpha]- and obesity-induced insulin resistance
JA  - Science
PY  - 1996///
VL  - 271
SP  - 665
EP  - 668
M3  - 10.1126/science.271.5249.665
N1  - 10.1126/science.271.5249.665
UR  - http://dx.doi.org/10.1126/science.271.5249.665
ER  -

TY  - JOUR
AU  - Aguirre, V.
AU  - Uchida, T.
AU  - Yenush, L.
AU  - Davis, R.
AU  - White, M. F.
TI  - The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307
JA  - J. Biol. Chem.
PY  - 2000///
VL  - 275
SP  - 9047
EP  - 9054
M3  - 10.1074/jbc.275.12.9047
N1  - 10.1074/jbc.275.12.9047
UR  - http://dx.doi.org/10.1074/jbc.275.12.9047
ER  -

TY  - JOUR
AU  - Paz, K.
TI  - Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation
JA  - J. Biol. Chem.
PY  - 1997///
VL  - 272
SP  - 29911
EP  - 29918
M3  - 10.1074/jbc.272.47.29911
N1  - 10.1074/jbc.272.47.29911
UR  - http://dx.doi.org/10.1074/jbc.272.47.29911
ER  -

TY  - JOUR
AU  - Emanuelli, B.
TI  - SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-[alpha] in the adipose tissue of obese mice
JA  - J. Biol. Chem.
PY  - 2001///
VL  - 276
SP  - 47944
EP  - 47949
ER  -

TY  - JOUR
AU  - Rui, L.
AU  - Yuan, M.
AU  - Frantz, D.
AU  - Shoelson, S.
AU  - White, M. F.
TI  - SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2
JA  - J. Biol. Chem.
PY  - 2002///
VL  - 277
SP  - 42394
EP  - 42398
M3  - 10.1074/jbc.C200444200
N1  - 10.1074/jbc.C200444200
UR  - http://dx.doi.org/10.1074/jbc.C200444200
ER  -

TY  - JOUR
AU  - Howard, J. K.
TI  - Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3
JA  - Nature Med.
PY  - 2004///
VL  - 10
SP  - 734
EP  - 738
M3  - 10.1038/nm1072
N1  - 10.1038/nm1072
UR  - http://dx.doi.org/10.1038/nm1072
ER  -

TY  - JOUR
AU  - Gao, Z.
TI  - Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex
JA  - J. Biol. Chem.
PY  - 2002///
VL  - 277
SP  - 48115
EP  - 48121
M3  - 10.1074/jbc.M209459200
N1  - 10.1074/jbc.M209459200
UR  - http://dx.doi.org/10.1074/jbc.M209459200
ER  -

TY  - JOUR
AU  - Griffin, M. E.
TI  - Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
JA  - Diabetes
PY  - 1999///
VL  - 48
SP  - 1270
EP  - 1274
ER  -

TY  - JOUR
AU  - Hotamisligil, G. S.
TI  - IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-[alpha]- and obesity-induced insulin resistance
JA  - Science
PY  - 1996///
VL  - 271
SP  - 665
EP  - 668
M3  - 10.1126/science.271.5249.665
N1  - 10.1126/science.271.5249.665
UR  - http://dx.doi.org/10.1126/science.271.5249.665
ER  -

TY  - JOUR
AU  - Zick, Y.
TI  - Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance
JA  - Sci. STKE 2005
PY  - 2005///
SP  - pe4
ER  -

TY  - JOUR
AU  - Baud, V.
AU  - Karin, M.
TI  - Signal transduction by tumor necrosis factor and its relatives
JA  - Trends Cell Biol.
PY  - 2001///
VL  - 11
SP  - 372
EP  - 377
M3  - 10.1016/S0962-8924(01)02064-5
N1  - 10.1016/S0962-8924(01)02064-5
UR  - http://dx.doi.org/10.1016/S0962-8924(01)02064-5
ER  -

TY  - JOUR
AU  - Hirosumi, J.
TI  - A central role for JNK in obesity and insulin resistance
JA  - Nature
PY  - 2002///
VL  - 420
SP  - 333
EP  - 336
M3  - 10.1038/nature01137
N1  - 10.1038/nature01137
UR  - http://dx.doi.org/10.1038/nature01137
ER  -

TY  - JOUR
AU  - Prada, P. O.
TI  - Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion
JA  - Endocrinology
PY  - 2005///
VL  - 146
SP  - 1576
EP  - 1587
ER  -

TY  - JOUR
AU  - Ozcan, U.
TI  - Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
JA  - Science
PY  - 2004///
VL  - 306
SP  - 457
EP  - 461
M3  - 10.1126/science.1103160
N1  - 10.1126/science.1103160
UR  - http://dx.doi.org/10.1126/science.1103160
ER  -

TY  - JOUR
AU  - Tuncman, G.
TI  - Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance
JA  - Proc. Natl Acad. Sci. USA
PY  - 2006///
VL  - 103
SP  - 10741
EP  - 10746
M3  - 10.1073/pnas.0603509103
N1  - 10.1073/pnas.0603509103
UR  - http://dx.doi.org/10.1073/pnas.0603509103
ER  -

TY  - JOUR
AU  - Ricci, R.
TI  - Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis
JA  - Science
PY  - 2004///
VL  - 306
SP  - 1558
EP  - 1561
M3  - 10.1126/science.1101909
N1  - 10.1126/science.1101909
UR  - http://dx.doi.org/10.1126/science.1101909
ER  -

TY  - JOUR
AU  - Kaneto, H. N. Y.
TI  - Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide
JA  - Nature Med.
PY  - 2004///
VL  - 10
SP  - 1128
EP  - 1132
M3  - 10.1038/nm1111
N1  - 10.1038/nm1111
UR  - http://dx.doi.org/10.1038/nm1111
ER  -

TY  - JOUR
AU  - Liu, G.
AU  - Rondinone, C. M.
TI  - JNK: bridging the insulin signaling and inflammatory pathway
JA  - Curr. Opin. Investig. Drugs
PY  - 2005///
VL  - 6
SP  - 979
EP  - 987
ER  -

TY  - JOUR
AU  - Yuan, M.
TI  - Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted distruption of Ikk[beta]
JA  - Science
PY  - 2001///
VL  - 293
SP  - 1673
EP  - 1677
M3  - 10.1126/science.1061620
N1  - 10.1126/science.1061620
UR  - http://dx.doi.org/10.1126/science.1061620
ER  -

TY  - JOUR
AU  - Hundal, R. S.
TI  - Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes
JA  - J. Clin. Invest.
PY  - 2002///
VL  - 109
SP  - 1321
EP  - 1326
M3  - 10.1172/JCI200214955
N1  - 10.1172/JCI200214955
UR  - http://dx.doi.org/10.1172/JCI200214955
ER  -

TY  - JOUR
AU  - Cai, D.
TI  - Local and systemic insulin resistance resulting from hepatic activation of IKK-[beta] and NF-[kappa]B
JA  - Nature Med.
PY  - 2005///
VL  - 11
SP  - 183
EP  - 190
M3  - 10.1038/nm1166
N1  - 10.1038/nm1166
UR  - http://dx.doi.org/10.1038/nm1166
ER  -

TY  - JOUR
AU  - Kim, J. K.
TI  - PKC-theta knockout mice are protected from fat-induced insulin resistance
JA  - J. Clin. Invest.
PY  - 2004///
VL  - 114
SP  - 823
EP  - 827
M3  - 10.1172/JCI200422230
N1  - 10.1172/JCI200422230
UR  - http://dx.doi.org/10.1172/JCI200422230
ER  -

TY  - JOUR
AU  - Boden, G.
TI  - Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver
JA  - Diabetes
PY  - 2005///
VL  - 54
SP  - 3458
EP  - 3465
ER  -

TY  - JOUR
AU  - Liu, J.
TI  - NF-[kappa]B is required for UV-induced JNK activation via induction of PKC[delta]
JA  - Mol. Cell
PY  - 2006///
VL  - 21
SP  - 467
EP  - 480
M3  - 10.1016/j.molcel.2005.12.020
N1  - 10.1016/j.molcel.2005.12.020
UR  - http://dx.doi.org/10.1016/j.molcel.2005.12.020
ER  -

TY  - JOUR
AU  - Marciniak, S. J.
AU  - Ron, D.
TI  - Endoplasmic reticulum stress signaling in disease
JA  - Physiol. Rev.
PY  - 2006///
VL  - 86
SP  - 1133
EP  - 1149
M3  - 10.1152/physrev.00015.2006
N1  - 10.1152/physrev.00015.2006
UR  - http://dx.doi.org/10.1152/physrev.00015.2006
ER  -

TY  - JOUR
AU  - Schroder, M.
AU  - Kaufman, R. J.
TI  - The mammalian unfolded protein response
JA  - Annu. Rev. Biochem.
PY  - 2005///
VL  - 74
SP  - 739
EP  - 789
M3  - 10.1146/annurev.biochem.73.011303.074134
N1  - 10.1146/annurev.biochem.73.011303.074134
UR  - http://dx.doi.org/10.1146/annurev.biochem.73.011303.074134
ER  -

TY  - JOUR
AU  - Harding, H. P.
AU  - Zhang, Y.
AU  - Bertolotti, A.
AU  - Zeng, H.
AU  - Ron, D.
TI  - Perk is essential for translational regulation and cell survival during the unfolded protein response
JA  - Mol. Cell
PY  - 2000///
VL  - 5
SP  - 897
EP  - 904
M3  - 10.1016/S1097-2765(00)80330-5
N1  - 10.1016/S1097-2765(00)80330-5
UR  - http://dx.doi.org/10.1016/S1097-2765(00)80330-5
ER  -

TY  - JOUR
AU  - Harding, H. P.
AU  - Zhang, Y.
AU  - Ron, D.
TI  - Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
JA  - Nature
PY  - 1999///
VL  - 397
SP  - 271
EP  - 274
M3  - 10.1038/16729
N1  - 10.1038/16729
UR  - http://dx.doi.org/10.1038/16729
ER  -

TY  - JOUR
AU  - Urano, F.
TI  - Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
JA  - Science
PY  - 2000///
VL  - 287
SP  - 664
EP  - 666
M3  - 10.1126/science.287.5453.664
N1  - 10.1126/science.287.5453.664
UR  - http://dx.doi.org/10.1126/science.287.5453.664
ER  -

TY  - JOUR
AU  - Deng, J. L.P.
TI  - Translational repression mediates activation of nuclear factor [kappa] B by phosphorylated translation initiation factor 2
JA  - Mol. Cell. Biol.
PY  - 2004///
VL  - 24
SP  - 10161
EP  - 10168
M3  - 10.1128/MCB.24.23.10161-10168.2004
N1  - 10.1128/MCB.24.23.10161-10168.2004
UR  - http://dx.doi.org/10.1128/MCB.24.23.10161-10168.2004
ER  -

TY  - JOUR
AU  - Hu, P. H. Z.
AU  - Couvillon, A. D.
AU  - Kaufman, R. J.
AU  - Exton, J. H.
TI  - Autocrine tumor necrosis factor [alpha] links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1[alpha]-mediated NF-[kappa]B activation and down-regulation of TRAF2 expression
JA  - Mol. Cell. Biol.
PY  - 2006///
VL  - 26
SP  - 3071
EP  - 3084
M3  - 10.1128/MCB.26.8.3071-3084.2006
N1  - 10.1128/MCB.26.8.3071-3084.2006
UR  - http://dx.doi.org/10.1128/MCB.26.8.3071-3084.2006
ER  -

TY  - JOUR
AU  - Ozawa, K.
TI  - The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes
JA  - Diabetes
PY  - 2005///
VL  - 54
SP  - 657
EP  - 663
ER  -

TY  - JOUR
AU  - Nakatani, Y.
TI  - Involvement of endoplasmic reticulum stress in insulin resistance and diabetes
JA  - J. Biol. Chem.
PY  - 2005///
VL  - 280
SP  - 847
EP  - 851
ER  -

TY  - JOUR
AU  - Ozcan, U.
TI  - Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
JA  - Science
PY  - 2006///
VL  - 313
SP  - 1137
EP  - 1140
M3  - 10.1126/science.1128294
N1  - 10.1126/science.1128294
UR  - http://dx.doi.org/10.1126/science.1128294
ER  -

TY  - JOUR
AU  - Zhang, K. S. X.
TI  - Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
JA  - Cell
PY  - 2006///
VL  - 124
SP  - 587
EP  - 599
M3  - 10.1016/j.cell.2005.11.040
N1  - 10.1016/j.cell.2005.11.040
UR  - http://dx.doi.org/10.1016/j.cell.2005.11.040
ER  -

TY  - JOUR
AU  - Cullinan, S. B.
AU  - Diehl, J. A.
TI  - Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway
JA  - Int. J. Biochem. Cell Biol.
PY  - 2006///
VL  - 38
SP  - 317
EP  - 332
M3  - 10.1016/j.biocel.2005.09.018
N1  - 10.1016/j.biocel.2005.09.018
UR  - http://dx.doi.org/10.1016/j.biocel.2005.09.018
ER  -

TY  - JOUR
AU  - Xue, X. P. J.
TI  - Tumor necrosis factor [alpha] (TNF[alpha]) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNF[alpha]
JA  - J. Biol. Chem.
PY  - 2005///
VL  - 280
SP  - 33917
EP  - 33925
M3  - 10.1074/jbc.M505818200
N1  - 10.1074/jbc.M505818200
UR  - http://dx.doi.org/10.1074/jbc.M505818200
ER  -

TY  - JOUR
AU  - Furukawa, S.
TI  - Increased oxidative stress in obesity and its impact on metabolic syndrome
JA  - J. Clin. Invest.
PY  - 2004///
VL  - 114
SP  - 1752
EP  - 1761
M3  - 10.1172/JCI200421625
N1  - 10.1172/JCI200421625
UR  - http://dx.doi.org/10.1172/JCI200421625
ER  -

TY  - JOUR
AU  - Lin, Y.
TI  - The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species
JA  - J. Biol. Chem.
PY  - 2005///
VL  - 280
SP  - 4617
EP  - 4626
ER  -

TY  - JOUR
AU  - Houstis, N.
AU  - Rosen, E. D.
AU  - Lander, E. S.
TI  - Reactive oxygen species have a causal role in multiple forms of insulin resistance
JA  - Nature
PY  - 2006///
VL  - 440
SP  - 944
EP  - 948
M3  - 10.1038/nature04634
N1  - 10.1038/nature04634
UR  - http://dx.doi.org/10.1038/nature04634
ER  -

TY  - JOUR
AU  - Brownlee, M.
TI  - Biochemistry and molecular cell biology of diabetic complications
JA  - Nature
PY  - 2001///
VL  - 414
SP  - 813
EP  - 820
M3  - 10.1038/414813a
N1  - 10.1038/414813a
UR  - http://dx.doi.org/10.1038/414813a
ER  -

TY  - JOUR
AU  - Lowell, B. B.
AU  - Shulman, G. I.
TI  - Mitochondrial dysfunction and type 2 diabetes
JA  - Science
PY  - 2005///
VL  - 307
SP  - 384
EP  - 387
M3  - 10.1126/science.1104343
N1  - 10.1126/science.1104343
UR  - http://dx.doi.org/10.1126/science.1104343
ER  -

TY  - JOUR
AU  - Steen, E.
TI  - Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease [mdash] is this type 3 diabetes?
JA  - J. Alzheimers Dis.
PY  - 2005///
VL  - 7
SP  - 63
EP  - 80
ER  -

TY  - JOUR
AU  - Mootha, V. K.
TI  - PGC-1[alpha]-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
JA  - Nature Genet.
PY  - 2003///
VL  - 34
SP  - 267
EP  - 273
M3  - 10.1038/ng1180
N1  - 10.1038/ng1180
UR  - http://dx.doi.org/10.1038/ng1180
ER  -

TY  - JOUR
AU  - St-Pierre, J.
TI  - Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
JA  - Cell
PY  - 2006///
VL  - 127
SP  - 397
EP  - 408
ER  -

TY  - JOUR
AU  - Gao, Z.
AU  - Zuberi, A.
AU  - Quon, M. J.
AU  - Dong, Z.
AU  - Ye, J.
TI  - Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases
JA  - J. Biol. Chem.
PY  - 2003///
VL  - 278
SP  - 24944
EP  - 24950
M3  - 10.1074/jbc.M300423200
N1  - 10.1074/jbc.M300423200
UR  - http://dx.doi.org/10.1074/jbc.M300423200
ER  -

TY  - JOUR
AU  - Waeber, G.
TI  - The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes
JA  - Nature Genet.
PY  - 2000///
VL  - 24
SP  - 291
EP  - 295
M3  - 10.1038/73523
N1  - 10.1038/73523
UR  - http://dx.doi.org/10.1038/73523
ER  -

TY  - JOUR
AU  - Kliewer, S. A.
AU  - Xu, H. E.
AU  - Lambert, M. H.
AU  - Wilson, T. M.
TI  - Peroxisome proliferator-activated receptors: from genes to physiology
JA  - Recent Prog. Horm. Res.
PY  - 2001///
VL  - 56
SP  - 239
EP  - 263
M3  - 10.1210/rp.56.1.239
N1  - 10.1210/rp.56.1.239
UR  - http://dx.doi.org/10.1210/rp.56.1.239
ER  -

TY  - JOUR
AU  - Mahata, B.
AU  - Mukherjee, S.
AU  - Mishra, S.
AU  - Bandyopadhyay, A.
AU  - Adhya, S.
TI  - Functional delivery of a cytosolic tRNA into mutant mitochondria of human cells
JA  - Science
PY  - 2006///
VL  - 314
SP  - 471
EP  - 474
M3  - 10.1126/science.1129754
N1  - 10.1126/science.1129754
UR  - http://dx.doi.org/10.1126/science.1129754
ER  -
