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Nature 444, 847-853 (14 December 2006) | doi:10.1038/nature05483; Published online 13 December 2006
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Assistant Editor – Nature Immunology
- Nature Publishing Group
- New York, NY United States
Assoc. Scientific Manager / Scientific Manager - Biopharmaceutics
- Syngene International
- Bangalore, Karnataka 560099 India
Review Article Adipocytes as regulators of energy balance and glucose homeostasis
Evan D. Rosen1 & Bruce M. Spiegelman2
Abstract
Adipocytes have been studied with increasing intensity as a result of the emergence of obesity as a serious public health problem and the realization that adipose tissue serves as an integrator of various physiological pathways. In particular, their role in calorie storage makes adipocytes well suited to the regulation of energy balance. Adipose tissue also serves as a crucial integrator of glucose homeostasis. Knowledge of adipocyte biology is therefore crucial for understanding the pathophysiological basis of obesity and metabolic diseases such as type 2 diabetes. Furthermore, the rational manipulation of adipose physiology is a promising avenue for therapy of these conditions.
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