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Nature 444, 824-827 (14 December 2006) | doi:10.1038/nature05409; Published online 6 December 2006

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Malaria: A protective paradox

Stephen L. Hoffman1

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The infectious form of the malaria parasite has thousands of proteins, making it tough to develop a vaccine for it. Narrowing down which proteins cause protective immune responses may help resolve the problem.

A vaccine against malaria would be the ideal means of preventing the hundreds of millions of cases of the disease that occur annually across the globe1. But no malaria vaccine has yet been licensed, and there is little consensus on how to develop one.

  1. Stephen L. Hoffman is at Sanaria Inc., 12115 Parklawn Drive, Suite L, Rockville, Maryland 20852, USA.
    Email: slhoffman@sanaria.com

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