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Nature 444, 833-834 (14 December 2006) | doi:10.1038/444833a; Published online 13 December 2006
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- Julius-Maximilians Universitat Wurzburg
- Wurzburg Germany
Postdoctoral Fellow - Computational Genomics - Team 78 – Ref: 80464
- Wellcome Trust Sanger Institute
- Hinxton, Cambridgeshire CB10 1, UK
Diabetes: Kicking off the insulin cascade
Catherine Jackson1
Abstract
Inhibition of the insulin-signalling pathway leads to insulin resistance, an early step in the development of type 2 diabetes. A novel family of protein activators seems to act near the pathway's inception.
Many of the cellular processes that are vital for human health are regulated by the insulin/insulin-like growth factor signalling pathway, including glucose homeostasis, fat metabolism, cell growth and differentiation, and ageing1, 2. Defects in this pathway are central to the development of obesity and related diseases such as diabetes, in cancer and in the process of ageing.
- Catherine Jackson is in the Laboratory of Enzymology and Structural Biochemistry, Bat 34, CNRS, 91198 Gif sur Yvette, France.
Email: catherine.jackson@lebs.cnrs-gif.fr
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