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Nature 444, 827-828 (14 December 2006) | doi:10.1038/444827a; Published online 13 December 2006
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Assistant Professor
- University of Michigan
- Michigan, MI 48109 United States
Professor of Nanotechnology
- University of Southampton
- Southampton United Kingdom
Leukaemia: Niche retreats for stem cells
David A. Williams1 & Jose A. Cancelas2
Abstract
Leukaemic cells and normal blood-producing cells relate differently to their surroundings. This concept has now been extended to leukaemic stem cells, suggesting a fresh approach to therapy.
Maintaining good neighbourhood relations is important for all cells in multicellular organisms. The complex interactions between adjacent cells and with their local microenvironment support the growth, development and function of the cells — and cancer cells are no exception.
- David A. Williams is in the Division of Experimental Hematology, Cincinnati Children's Research Foundation, Cincinnati, Ohio 45229, USA.
- Jose A. Cancelas is in the Hoxworth Blood Center, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA.
Email: David.Williams@cchmc.org
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