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Nature 444, 805 (14 December 2006) | doi:10.1038/444805a; Published online 13 December 2006

In brief

The world's largest drug company is facing some turbulence after a large human trial of its cholesterol drug candidate torcetrapib was abandoned. The 2 December announcement that the trial would end, due to an unexpectedly high death rate among its participants, caused Pfizers's shares to fall from almost $28 to $25, knocking about $20 billion off its market capitulation.