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From the following article:

An SCN9A channelopathy causes congenital inability to experience pain

James J. Cox, Frank Reimann, Adeline K. Nicholas, Gemma Thornton, Emma Roberts, Kelly Springell, Gulshan Karbani, Hussain Jafri, Jovaria Mannan, Yasmin Raashid, Lihadh Al-Gazali, Henan Hamamy, Enza Maria Valente, Shaun Gorman, Richard Williams, Duncan P. McHale, John N. Wood, Fiona M. Gribble and C. Geoffrey Woods

Nature 444, 894-898(14 December 2006)

doi:10.1038/nature05413

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

The families used to map the locus for channelopathy-associated insensitivity to pain.

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Figure 2

Sequence chromatograms showing the mutations identified in families 1, 2 and 3.

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Figure 3

Schematic representation of Nav1.7, the voltage-gated sodium channel alpha-subunit encoded by SCN9A, and the locations of the identified human mutations.

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Figure 4

Patch-clamping experiments to investigate the voltage-gated sodium channel activity of wild-type and truncated Nav1.7.

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