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Nature 444, 761-765 (7 December 2006) | doi:10.1038/nature05349;
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Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells
Transformed, oncogenic precursors, possessing both defining neural-stem-cell properties and the ability to initiate intracerebral tumours, have been identified in human brain cancers. Here we report that bone morphogenetic proteins (BMPs), amongst which BMP4 elicits the strongest effect, trigger a significant reduction in the stem-like, tumour-initiating precursors of human glioblastomas (GBMs).
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