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Nature 444, 629-632 (15 November 2006) | doi:10.1038/nature05287;
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Repression of p53 activity by Smyd2-mediated methylation
Specific sites of lysine methylation on histones correlate with either activation or repression of transcription. The tumour suppressor p53 (refs 4–7) is one of only a few non-histone proteins known to be regulated by lysine methylation.
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