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Volume 444 Issue 7119, 30 November 2006

Editorial

  • The ITER fusion project demonstrates a solidity of purpose that is sorely lacking across the rest of the energy research spectrum.

    Editorial

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  • Regulators are beginning cautiously to navigate the uncharted waters of nanotechnology.

    Editorial
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Research Highlights

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News

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News in Brief

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Business

  • Drug companies lose hundreds of millions of dollars when large-scale human clinical trials fail. Helen Pearson examines whether alternative procedures could help avoid such disappointments.

    Business
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News Feature

  • The ancient Antikythera Mechanism doesn't just challenge our assumptions about technology transfer over the ages — it gives us fresh insights into history itself.

    • Jo Marchant
    News Feature
  • Understanding the trade-offs involved for plants making leaves promises fresh insights on every scale from the plant to the planet, finds John Whitfield

    • John Whitfield
    News Feature
  • Research suggests that consuming soil may have more health implications than one might expect. Trevor Stokes sieves through the reasons why people include dirt in their diet.

    • Trevor Stokes
    News Feature
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Correspondence

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Books & Arts

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News & Views

  • The Antikythera Mechanism, salvaged 100 years ago from an ancient shipwreck, was long known to be some sort of mechanical calendar. But modern analysis is only now revealing just how sophisticated it was.

    • François Charette
    News & Views
  • Stem-cell therapy is valued for its potential to restore damaged or degenerating tissues. Stem cells are now regularly used to renew blood, and it looks as if the next success could be in treating dystrophic muscle.

    • Jeffrey S. Chamberlain
    News & Views
  • Slipping in extra benzene rings creates a broader DNA double helix that is similar to, but different from, natural DNA. Importantly, it can encode more genetic information — and that could have wide implications.

    • Aaron M. Leconte
    • Floyd E. Romesberg
    News & Views
  • Rare species have to cope not only with habitat loss, genetic bottlenecks and invasive competitors, but also with a self-reinforcing cycle of human greed. This last threat has now been dragged into the spotlight.

    • Barry W. Brook B W
    • Navjot S. Sodhi N S
    News & Views
  • Intermediate compounds are often produced during a chemical reaction, but they are too short-lived to be easily observed. It seems that a molecular pyramid can persuade them to stick around for a little longer.

    • Julius Rebek Jr
    News & Views
  • It is generally agreed that sleep aids memory consolidation, but the reasons for this are a mystery. Part of the answer may lie in the patterns of synchronous brain activity unique to the state of slumber.

    • Robert Stickgold
    News & Views
  • Tiny metal resonators can be used to create a material with tunable responses to an applied voltage. Combined with a semiconductor substrate, they can be used to control technologically promising terahertz radiation.

    • Mittleman Daniel
    News & Views
  • Cells of the same type can generate diverse sets of physiological traits from a single set of genes. Part of this diversity could stem from 'noise' that arises from variations in the way proteins are expressed.

    • John R. S. Newman
    • Jonathan S. Weissman
    News & Views
  • Data on changes in water storage in the Congo basin show how GRACE, a pair of satellites designed to record variations in Earth's gravitational field, is benefiting the study of the planet's water cycle.

    • Dennis P. Lettenmaier
    • James S. Famiglietti
    News & Views
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Brief Communication

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Review Article

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Article

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Letter

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Prospects

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Special Report

  • Is interest in biofuels in the United States a just fad or a growing trend that will yield numerous jobs and research opportunities? Gene Russo separates the wheat from the chaff.

    • Gene Russo
    Special Report
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Futures

  • Last delivery before the Singularity.

    • Catherine H. Shaffer
    Futures
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Authors

  • How electrical oscillations during sleep help us to remember things.

    Authors
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Brief Communications Arising

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