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Nature 444, 561-562 (30 November 2006) | doi:10.1038/nature05407; Published online 19 November 2006

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Systems Biology: Many things from one

John R. S. Newman1 & Jonathan S. Weissman1

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Cells of the same type can generate diverse sets of physiological traits from a single set of genes. Part of this diversity could stem from 'noise' that arises from variations in the way proteins are expressed.

The census bureau will tell you that the typical American family has 2.1 children, but there are no families (we hope) that precisely match this mean.

  1. John R. S. Newman and Jonathan S. Weissman are in the Department of Cellular and Molecular Pharmacology, and at the Howard Hughes Medical Institute, University of California, San Francisco, Byers Hall 403B, 1700 4th Street, San Francisco, California 94158-2330, USA.

Correspondence to: John R. S. Newman1 Email: jrsnewman@alum.mit.edu

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