Slipping in extra benzene rings creates a broader DNA double helix that is similar to, but different from, natural DNA. Importantly, it can encode more genetic information — and that could have wide implications.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Watson, J. D. & Crick, F. H. Nature 171, 737–738 (1953).
Liu, H. et al. Science 302, 868–871 (2003).
Lynch, S. R., Liu, H., Gao, J. & Kool, E. T. J. Am. Chem. Soc. 128, 14704–14711 (2006).
Leonard, N. J. Acc. Chem. Res. 15, 128–135 (1982).
Seley, K. L., Quirk, S., Salim, S., Zhang, L. & Hagos, A. Bioorg. Med. Chem. Lett. 13, 1985–1988 (2003).
Zhang, N. et al. J. Med. Chem. 46, 4776–4789 (2003).
Gao, J., Liu, H. & Kool, E. T. Angew. Chem. Int. Edn 44, 3118–3122 (2005).
Henry, A. A. & Romesberg, F. E. Curr. Opin. Chem. Biol. 7, 727–733 (2003).
Johnson, S. J. & Beese, L. S. Cell 116, 803–816 (2004).
Henry, A. A. & Romesberg, F. E. Curr. Opin. Biotechnol. 16, 370–377 (2005).
Lee, A. H. & Kool, E. T. J. Am. Chem. Soc. 127, 3332–3338 (2005).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Leconte, A., Romesberg, F. A broader take on DNA. Nature 444, 553–555 (2006). https://doi.org/10.1038/444553a
Published:
Issue Date:
DOI: https://doi.org/10.1038/444553a
