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From the following article:

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

Raffaella Di Micco, Marzia Fumagalli, Angelo Cicalese, Sara Piccinin, Patrizia Gasparini, Chiara Luise, Catherine Schurra, Massimiliano Garre', Paolo Giovanni Nuciforo, Aaron Bensimon, Roberta Maestro, Pier Giuseppe Pelicci and Fabrizio d'Adda di Fagagna

Nature 444, 638-642(30 November 2006)

doi:10.1038/nature05327

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Figure 1

DNA damage accumulation and DDR activation in OIS cells.

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Figure 2

DDR inactivation abolishes OIS.

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Figure 3

DDR inactivation promotes cell transformation.

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Figure 4

Oncogene expression leads to alterations of DNA replication.

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