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Nature 444, 256-257 (16 November 2006) | doi:10.1038/444256a; Published online 15 November 2006

Open Innovation Challenges

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The chips are down

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Geneticists' desire to track the roots of complex diseases has shaken up the market for gene chips. Meredith Wadman reports on two firms jostling for position in a business potentially worth US$500 million.

Wall Street analyst Elise Wang began her coverage of the Goliath of gene-chip makers last month with an unequivocal recommendation: sell.Her advice came despite the fact that shares in Affymetrix, the company based in Santa Clara, California, whose scientists invented the gene chip 17 years ago, are already trading down by almost 50% from where they were a year ago (see graph).